{"created":"2023-07-27T06:44:24.968680+00:00","id":34631,"links":{},"metadata":{"_buckets":{"deposit":"e14949fe-bf38-4496-af48-d58b5646be10"},"_deposit":{"created_by":3,"id":"34631","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34631"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034631","sets":["2812:2813:2823"]},"author_link":["111","81233"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-02","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kikuchi, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"81233","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00377384","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00377384"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"DTIを用いて広汎性発達障害者20名、気分障害と広汎性発達障害の合併患者4名、健常コントロール18名を対象に、解剖学的ネットワークについて検討した。広汎性発達障害の患者においては、脳梁においてFA値が低下していた。特に両疾患の合併例においては、Superior longitudinal fasciculusにおいてFA値が有意に低下していた。MRSの施行によるGABA測定については、撮像時間が長く、被験者への負担が大きいことから、解析可能なサンプル数には至っていない。今回の研究で、広汎性発達障害の大脳皮質のネットワーク障害を形態学的に示した。","subitem_description_type":"Abstract"},{"subitem_description":"White matter abnormalities can be detected by diffusion tensor imaging (DTI). DTI is a noninvasive MRI technique that is useful for investigating white matter structure, an important aspect of brain connectivity. Autism spectrum disorder (ASD) (n=20) and ASD with bipolar disorder (ASD with BP) (n=4) were compared control subject (n=18). Our results demonstrated that ASD group showed reduced fractional anisotropy (FA) in splenium of corpus callosum, and that ASD with BP group showed reduced FA in superior longitudinal fasciculus. Our results suggested the deviated anatomical brain network in ASD patients.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20591394, 研究期間(年度):2008–2010","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「自閉症スペクトラムの病態におけるGABA系の関与」課題番号20591394\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591394/20591394seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034618","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00377384","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591394/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591394/20591394seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"菊知, 充"}],"nameIdentifiers":[{"nameIdentifier":"111","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00377384","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00377384"},{"nameIdentifier":"00377384","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=00377384"},{"nameIdentifier":"00377384","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000000377384"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"CH-PR-KIKUCHI-M-kaken 2011-6p.pdf","filesize":[{"value":"472.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CH-PR-KIKUCHI-M-kaken 2011-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34631/files/CH-PR-KIKUCHI-M-kaken 2011-6p.pdf"},"version_id":"bd730a28-61f4-49a9-a2e8-aae3f602d2a2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"自閉症スペクトラムの病態におけるGABA系の関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"自閉症スペクトラムの病態におけるGABA系の関与"},{"subitem_title":"GABAergic system and brain network in Autism spectrum disorder","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34631","relation_version_is_last":true,"title":["自閉症スペクトラムの病態におけるGABA系の関与"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2024-07-01T06:01:56.195242+00:00"}