{"created":"2023-07-27T06:44:25.409654+00:00","id":34641,"links":{},"metadata":{"_buckets":{"deposit":"438ff8cb-913e-46de-8f7c-7c24f227b793"},"_deposit":{"created_by":3,"id":"34641","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34641"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034641","sets":["2812:2813:2823"]},"author_link":["85909","86"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"胎盤関門の物質輸送を担うトランスポータータンパク質複合体の制御因子としてエズリンの役割を解明することを目的とした。胎盤関門細胞株TR-TBTsや妊娠ラット、エズリン遺伝子欠損マウスを用いて研究を行ったところ、エズリンは合胞体性栄養膜細胞の母体血側細胞膜の裏打ちタンパク質として妊娠経過に伴う胎盤の成熟と共に時期特異的に発現し、ヒポタウリン輸送系(Slc6a13)やその他の輸送系を細胞膜へ局在化させる機能を担うとともに機能調節因子として働くことが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"This study was aimed to clarify the regulatory role of ezrin on transporter complex (transportsome) at the placenta barrier. Our study using syncytiotrophoblast cell line TR-TBTs, pregnant rats as well as knockout mice lacking ezrin, scaffold protein that links membrane proteins to the cortical actin, have suggested that ezrin is located at the apical membrane of syncytiotrophoblasts during the course of pregnancy and works as a functional regulator in the transportsome containing a hypotaurin transporter Slc6a13.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20590158, 研究期間(年度):2008– 2010","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「胎盤関門のダイナミクスを制御するトランスポーター-エズリン複合体」課題番号20590158\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590158/20590158seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034628","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40262589","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590158/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590158/20590158seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"HO-PR-SAI-Y-kaken 2011-6p.pdf","filesize":[{"value":"313.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-SAI-Y-kaken 2011-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34641/files/HO-PR-SAI-Y-kaken 2011-6p.pdf"},"version_id":"2350ee6a-2295-436f-9f9d-2ad80e8fbc82"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胎盤関門のダイナミクスを制御するトランスポーター-エズリン複合体","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胎盤関門のダイナミクスを制御するトランスポーター-エズリン複合体"},{"subitem_title":"Regulatory role of ezrin on transportsome at the blood placenta barrier","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34641","relation_version_is_last":true,"title":["胎盤関門のダイナミクスを制御するトランスポーター-エズリン複合体"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T13:19:23.811288+00:00"}