{"created":"2023-07-27T06:44:25.453831+00:00","id":34642,"links":{},"metadata":{"_buckets":{"deposit":"9bfbb3b6-245a-4754-ab45-28004fa5907d"},"_deposit":{"created_by":3,"id":"34642","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34642"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034642","sets":["2812:2813:2823"]},"author_link":["2702"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"酪酸は,AMPKの活性化とHDAC阻害作用を併せもち脂肪酸β酸化経路を活性化させることにより肝臓の脂質代謝を改善する可能性が示唆された.Salacia reticulataは血清中adiponectinを上昇させ脂肪分解を亢進することで抗肥満効果を示すことが示唆された.葛花抽出物は肝臓および褐色脂肪に作用して抗肥満効果を示すことが示唆された.これらの結果は,非アルコール性脂肪肝炎(NASH)の病態解明と治療法の確立に寄与する重要な知見と考えられた.","subitem_description_type":"Abstract"},{"subitem_description":"It is suggested that butylic acid activates AMP-activated protein kinase (AMPK) and inhibits histone deacetylase (HDAC) thereby improves lipid metabolism in the liver by activating lipid β-oxidation. S. reticulata extract exhibited anti-obesity effect by increasing serum adiponectin and enhancing lipid metabolism. P. flos extract exhibited anti-obesity effect through an action on the liver and brown fat cell. These findings may facilitate clarification and treatment of non-alcoholic steatohepatitis (NASH).","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20590141, 研究期間(年度):2008–2010","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「NADPHオキシダーゼ阻害剤によるNASHの抗酸化療法の開発研究」課題番号20590141\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590141/20590141seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034629","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30100514","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590141/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590141/20590141seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"HO-PR-MIYAMOTO-K-kaken 2011-5p.pdf","filesize":[{"value":"255.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-MIYAMOTO-K-kaken 2011-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34642/files/HO-PR-MIYAMOTO-K-kaken 2011-5p.pdf"},"version_id":"f7e18188-c510-427c-881e-7f6cfe79bc68"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"NADPHオキシダーゼ阻害剤によるNASHの抗酸化療法の開発研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"NADPHオキシダーゼ阻害剤によるNASHの抗酸化療法の開発研究"},{"subitem_title":"Development of anti-oxidizing therapy of NASH using inhibitors of NADPH oxidase","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34642","relation_version_is_last":true,"title":["NADPHオキシダーゼ阻害剤によるNASHの抗酸化療法の開発研究"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T13:19:22.026242+00:00"}