{"created":"2023-07-27T06:44:25.633933+00:00","id":34646,"links":{},"metadata":{"_buckets":{"deposit":"a712f67e-685e-46cb-b118-0de8c48c916c"},"_deposit":{"created_by":3,"id":"34646","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34646"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034646","sets":["2812:2813:2823"]},"author_link":["1166","21459"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"再燃前立腺癌におけるエストロゲン療法の意義を再考すると共に,2種のエストロゲン受容体(ERαとERβ)を介したシグナル伝達機構について分子生物学的手法を用いて包括的に解析した.その結果,前立腺癌の増殖・進展においては,ERαが促進的にERβが抑制的に働く可能性が明らかになったと共に,ERβを標的とした分子標的治療の可能性とERβ発現ベクターとそのリガンドEstradiolを用いた遺伝子治療の可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"To reconsider a significance of Estrogen-based therapy in hormone refractory prostate cancer and elucidate a comprehensive mechanisms through which two type of Estrogen receptor, ERα and ERβ,can differently mediate signal transduction pathways. Consequently, our study made it clear that ERα might act as a pedal but ERβ as a brake in progression of prostate cancer, and also suggested the possibility of molecular targeting therapy for ERβ and gene therapy using ERβ expression vector and its ligand Estradiol.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「再燃前立腺癌におけるエストロゲン受容体を介したシグナル伝達機構の包括的解明」課題番号20591852\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591852/20591852seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034633","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=40334768","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591852/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591852/20591852seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"HO-PR-KONAKA-H-kaken 2011-5p.pdf","filesize":[{"value":"336.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-KONAKA-H-kaken 2011-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34646/files/HO-PR-KONAKA-H-kaken 2011-5p.pdf"},"version_id":"6ddb4926-a51c-4c07-9492-6ff1180c61be"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"再燃前立腺癌におけるエストロゲン受容体を介したシグナル伝達機構の包括的解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"再燃前立腺癌におけるエストロゲン受容体を介したシグナル伝達機構の包括的解明"},{"subitem_title":"Comprehensive elucidation of estrogen receptor mediated signal pathways in hormone refractory prostate cancer","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34646","relation_version_is_last":true,"title":["再燃前立腺癌におけるエストロゲン受容体を介したシグナル伝達機構の包括的解明"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T13:19:16.049204+00:00"}