{"created":"2023-07-27T06:44:25.899045+00:00","id":34652,"links":{},"metadata":{"_buckets":{"deposit":"23450933-ec12-434f-a0bd-b25736d584f2"},"_deposit":{"created_by":3,"id":"34652","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34652"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034652","sets":["2812:2813:2823"]},"author_link":["85283","85284"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-18","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年肝癌組織においても幹細胞様の性格を有する肝癌幹細胞の存在が明らかになり、癌治療の重要なターゲットと考えられている。本研究では、正常胎児肝において肝芽細胞を肝細胞へと分化誘導するサイトカインとして知られるOncostatin M(OSM)が肝がん幹細胞の分化誘導に応用可能であることを同定した。OSMは肝癌幹細胞の抗癌剤抵抗性を改善することから、癌治療における有力な標的分子であると考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"Recent evidence suggests that tumor cells possess stem cell features (cancer stem cells) to self-renew and give rise to relatively differentiated cells through asymmetric division, thereby forming heterogeneous populations. Cancer stem cells are considered to be resistant to chemotherapy and radiotherapy, which might be associated with the recurrence of the tumor after treatment. Oncostatin M (OSM) is a pleiotropic cytokine known to activate the hepatocytic differentiation program in hepatoblasts in an OSMR-specific manner. We identified that OSMR is expressed in a subset of liver cancer stem cells and OSM induces hepatocytic differentiation of these cells. OSM-mediated hepatocytic differentiation effectively suppressed HCC growth when combined with conventional chemotherapy, suggesting the utility of OSM for the treatment of liver cancer stem cells.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20599005, 研究期間(年度):2008–2010","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「肝発生分化メカニズムに基づいた肝癌幹細胞特異的治療法の開発」課題番号20599005\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20599005/20599005seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034639","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90377432","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20599005/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20599005/20599005seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"HO-PR-YAMASHITA-T-kaken 2011-4p.pdf","filesize":[{"value":"307.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-YAMASHITA-T-kaken 2011-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34652/files/HO-PR-YAMASHITA-T-kaken 2011-4p.pdf"},"version_id":"93776c61-e7c7-4975-b82f-c0347528bf59"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝発生分化メカニズムに基づいた肝癌幹細胞特異的治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝発生分化メカニズムに基づいた肝癌幹細胞特異的治療法の開発"},{"subitem_title":"Differentiation of liver cancer stem cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34652","relation_version_is_last":true,"title":["肝発生分化メカニズムに基づいた肝癌幹細胞特異的治療法の開発"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T13:18:49.650331+00:00"}