{"created":"2023-07-27T06:44:26.607560+00:00","id":34668,"links":{},"metadata":{"_buckets":{"deposit":"232e33cf-ec55-4517-b190-50cb11c04d62"},"_deposit":{"created_by":3,"id":"34668","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34668"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034668","sets":["2812:2813:2824"]},"author_link":["72722","266"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-04-04","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2007-2009","bibliographic_titles":[{"bibliographic_title":"平成21(2009)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2009 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"心房細動はその原因究明、対策が社会的に重要な不整脈である。心房細動は、肥大型心筋症患者の5～23%程度に発症し、また、明らかな基礎疾患を有さない孤立性心房細動も数多く存在し、その15%は家族歴を有することが知られている。我々は孤立性もしくは家族性心房細動75症例に対して遺伝子解析を行い、3種類の遺伝子変異を同定した。また、肥大型心筋症患者で、アンジオテンシンIIタイプI受容体A/C多型あるいはトロポニン遺伝子(TNNT2, TNNI3)変異を有する患者はより心房細動を発症しやすいことを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"Atrial fibrillation (AF) has an enormous social impact because of its very high incidence, its potential for devastating clinical consequences, and the difficulty of its management . Hypertrophic cardiomyopathy (HCM) is well known risk factor for AF. However, significant proportions of patients, up to 30% in some large studies, develop AF in the absence of risk factors. We performed genetic analysis for 75 patients with lone or familial AF, and identified 3 mutations. We also clarified that the HCM patients with angiotensinogen 1 A/C polymorphism, TNNT2 mutation, or TNNI3 mutation easily develop AF compared to those without these polymorphism or mutations.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「分子遺伝学的手法による心房細動発症機構の解明と心房細動アップストリーム治療の評価」課題番号19790520\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19790520/19790520seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034655","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00422642","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19790520/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19790520/19790520seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"HO-PR-HAYASHI-K-kaken 2010-6p.pdf","filesize":[{"value":"192.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HO-PR-HAYASHI-K-kaken 2010-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34668/files/HO-PR-HAYASHI-K-kaken 2010-6p.pdf"},"version_id":"1ae2394b-1693-41e9-8267-a15bc4d0aacc"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"分子遺伝学的手法による心房細動発症機構の解明と心房細動アップストリーム治療の評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"分子遺伝学的手法による心房細動発症機構の解明と心房細動アップストリーム治療の評価"},{"subitem_title":"Molecular genetics of atrial fibrillation and evaluation of upstream theraphy for atrial fibrillation","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2824"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34668","relation_version_is_last":true,"title":["分子遺伝学的手法による心房細動発症機構の解明と心房細動アップストリーム治療の評価"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T13:16:23.019885+00:00"}