{"created":"2023-07-27T06:44:27.931187+00:00","id":34699,"links":{},"metadata":{"_buckets":{"deposit":"18f01c8d-da7a-4def-93bb-7f351d6380cf"},"_deposit":{"created_by":3,"id":"34699","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34699"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034699","sets":["2812:2813:2825"]},"author_link":["129","76766"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-05-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2006-2008","bibliographic_titles":[{"bibliographic_title":"平成20(2008)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2008 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では, 原発性胆汁性肝硬変(PBC)における胆管消失に胆管細胞老化が関与することが明らかとなった. 人体材料を用いた検討では, PBCの傷害肝内小型胆管では高率に細胞老化マ-カ- : SA-ss-gal, p16^(INK4a), p21^(WAF1/Cip)の発現, テロメア長短縮を認めた. さらに酸化ストレス, 炎症性サイトカインにより培養胆管細胞に細胞老化が誘導され, その分子機構にはp16^<INK4a> 発現抑制因子bmi1発現低下、ATM /p53/p21経路経路が関与することが明らかとなった.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18590325, 研究期間(年度):2006–2008","subitem_description_type":"Other"},{"subitem_description":"出典：「原発性胆汁性肝硬変における胆管消失発生の分子機構:胆管細胞老化の関与を中心に」研究成果報告書　課題番号18590325\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18590325/18590325seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034686","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70225895","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590325/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18590325/18590325seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"ME-PR-SASAKI-M-kaken 2009-5p.pdf","filesize":[{"value":"295.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-SASAKI-M-kaken 2009-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34699/files/ME-PR-SASAKI-M-kaken 2009-5p.pdf"},"version_id":"df6ea700-cba5-49c3-ba7c-d9419a0db974"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"原発性胆汁性肝硬変における胆管消失発生の分子機構: 胆管細胞老化の関与を中心に","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"原発性胆汁性肝硬変における胆管消失発生の分子機構: 胆管細胞老化の関与を中心に"},{"subitem_title":"Pathogenesis of progressive bile duct loss in primary biliary cirrhosis: A possible involvement of cellular senescence","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2825"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34699","relation_version_is_last":true,"title":["原発性胆汁性肝硬変における胆管消失発生の分子機構: 胆管細胞老化の関与を中心に"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T14:16:06.388724+00:00"}