{"created":"2023-07-27T06:44:29.748191+00:00","id":34740,"links":{},"metadata":{"_buckets":{"deposit":"1f72e250-300e-4740-8f3a-589fd9ca7f31"},"_deposit":{"created_by":3,"id":"34740","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"34740"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00034740","sets":["2812:2813:2827"]},"author_link":["93871","155"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-05-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"9p.","bibliographicVolumeNumber":"2004-2006","bibliographic_titles":[{"bibliographic_title":"平成18(2006)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2006 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1.エナミドオレフィンに対する6-endo選択的アリールラジカル環化反応と、生じたアミドイルラジカルの5-endo環化反応を組み合わせたラジカルカスケードにより、13位にメチル基を有するフェナンスロインドリジジン類の簡便合成法を明らかにした。 2.エナミドオレフィンに対する6-endo選択的アルキルラジカル環化反応と、生じたアミドイルラジカルの5-endo環化反応を組み合わせたラジカルカスケードにより、シリンドリシン類の簡便構築法を明らかにした。 3.エナミドオレフィンに対する7-endo選択的アリールラジカル環化反応と、生じたアミドイルラジカルの5-endo環化反応を組み合わせたラジカルカスケードにより、セファロタキシン骨格の簡便構築法を明らかにした。 4.エナミドオレフィンに対する7-endo選択的アリールラジカル環化反応と、生じたアミドイルラジカルの芳香族置換反応を組み合わせることにより、イソインドロベンズアゼピンアルカロイド、レンノキサミンの短工程合成法を明らかにした。 5.エナミドオレフィンに対する7-endo選択的アルキル環化反応と、生じたアミドイルラジカルの5-endo環化反応を組み合わせたラジカルカスケードを用いることにより、ステモナミド類の全合成を達成した。 6.N-アリル-α,α,α-トリクロロアセトアミド類が、溶媒として用いた1,4-ジメチルピペラジン中加熱するだけでsingle electron transfer反応を起こして1つのクロル基を脱離し、ラジカル環化反応に基づく成績体を与えることを見出した 7.エナミドオレフィンに対するアルキルラジカル環化反応のexo選択性とendo選択性について詳細に検討した。","subitem_description_type":"Abstract"},{"subitem_description":"1. Radical cascade involving 6-endo selective cyclization of aryl radical onto olefinic bond of enamide and 5-endo cyclization of the resulting amidoyl radical afforded a convenient synthesis of phenanthroindolizidines containing a methyl group at their C13 position.\n2. Radical cascade involving 6-endo selective cyclization of alkyl radical onto olefinic bond of enamide and 5-endo cyclization of the resulting amidoyl radical afforded a convenient synthesis of cylindricine skeleton.\n3. Radical cascade involving 7-endo selective cyclization of aryl radical onto olefinic bond of enamide and 5-endo cyclization of the resulting amidoyl radical afforded a concise synthesis of cephalotoxine skeleton.\n4. Radical cascade involving 7-endo selective cyclization of aryl radical onto olefinic bond of enamide and homolytic aromatic substitution of the resulting amidoyl radical afforded a short synthesis of lennoxamine.\n5. Radical cascade involving 7-endo selective cyclization of alkyl radical onto olefinic bond of enamide and 5--endo cyclization of the resulting amidoyl radical afforded a total synthesis of stemonamide, isostemonamide, stemonamine, and isostemonamine.\n6. N-Allylic or N-vinylic, α, α, α-trichloroacetamides, upon heating in 1, 4-dimethylpiperazine, underwent radical cyclization to give the corresponding y-lactams.\n7. exo and endo Selectivities of aryl or alkyl radical onto olefinic bond of enamides were studied in detail.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:16390004, 研究期間(年度):2004–2006","subitem_description_type":"Other"},{"subitem_description":"出典：「実用的ラジカル反応の開発と生理活性化合物合成への応用」研究成果報告書　課題番号16390004\n  (KAKEN：科学研究費助成事業データベース（国立情報学研究所）)\n　　　本文データは著者版報告書より作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00034727","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学自然科学研究科"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70028869","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390004/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16390004/163900042006kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-05"}],"displaytype":"detail","filename":"PH-PR-ISHIBASHI-H-kaken 2007-9p.pdf","filesize":[{"value":"144.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-ISHIBASHI-H-kaken 2007-9p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/34740/files/PH-PR-ISHIBASHI-H-kaken 2007-9p.pdf"},"version_id":"baa28f47-b582-4df1-96a2-425cf9c794a6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"実用的ラジカル反応の開発と生理活性化合物合成への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"実用的ラジカル反応の開発と生理活性化合物合成への応用"},{"subitem_title":"Deve I opment of Practical Radical Reaction and its Applicat i on to the Synthesis of Physiologically Active Compounds","subitem_title_language":"en"}]},"item_type_id":"9","owner":"3","path":["2827"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-05"},"publish_date":"2017-10-05","publish_status":"0","recid":"34740","relation_version_is_last":true,"title":["実用的ラジカル反応の開発と生理活性化合物合成への応用"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T14:34:55.742929+00:00"}