{"created":"2023-07-27T06:48:28.769509+00:00","id":39997,"links":{},"metadata":{"_buckets":{"deposit":"2bbb68a3-c28a-46e1-b5a8-97a2162494d5"},"_deposit":{"created_by":3,"id":"39997","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"39997"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00039997","sets":["4161:3020:3021"]},"author_link":["63422","366","63420","63421"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-09-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"38","bibliographicPageStart":"384010","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"Nanotechnology"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"福間, 剛士"}],"nameIdentifiers":[{},{},{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have investigated the surface structure of islet amyloid polypeptide (IAPP) fibrils and α-synuclein protofibrils in liquid by means of frequency modulation atomic force microscopy (FM-AFM). Ångström- resolution FM-AFM imaging of isolated macromolecules in liquid is demonstrated for the first time. Individual β-strands aligned perpendicular to the fibril axis with a spacing of 0.5 nm are resolved in FM-AFM images, which confirms cross-β structure of IAPP fibrils in real space. FM-AFM images also reveal the existence of 4 nm periodic domains along the axis of IAPP fibrils. Stripe features with 0.5 nm spacing are also found in images of α-synuclein protofibrils. However, in contrast to the case for IAPP fibrils, the stripes are oriented 30° from the axis, suggesting the possibility of β-strand alignment in protofibrils different from that in mature fibrils or the regular arrangement of thioflavin T molecules present during the fibril preparation aligned at the surface of the protofibrils. © IOP Publishing Ltd.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学フロンティアサイエンス機構","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00039984","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Institute of Physics"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1088/0957-4484/19/38/384010","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA10863359","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0957-4484","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fukuma, Takeshi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Mostaert, Anika S."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Serpell, Louise C."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Jarvis, Suzanne P."}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-06"}],"displaytype":"detail","filename":"FS-PR-FUKUMA-T-384010.pdf","filesize":[{"value":"118.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"FS-PR-FUKUMA-T-384010.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/39997/files/FS-PR-FUKUMA-T-384010.pdf"},"version_id":"1188946a-59c8-4f1a-8429-4616439dc98b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Revealing molecular-level surface structure of amyloid fibrils in liquid by means of frequency modulation atomic force microscopy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Revealing molecular-level surface structure of amyloid fibrils in liquid by means of frequency modulation atomic force microscopy"}]},"item_type_id":"4","owner":"3","path":["3021"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-06"},"publish_date":"2017-10-06","publish_status":"0","recid":"39997","relation_version_is_last":true,"title":["Revealing molecular-level surface structure of amyloid fibrils in liquid by means of frequency modulation atomic force microscopy"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T10:35:25.040730+00:00"}