@article{oai:kanazawa-u.repo.nii.ac.jp:00042076,
 author = {林, 康彦 and 笹川, 泰生 and 喜多, 大輔 and 立花, 修 and 植田, 文明 and 中田, 光俊 and Hayashi, Yasuhiko and Sasagawa, Yasuo and Kita, Daisuke and Fukui, Issei and Oishi, Masahiro and Tachibana, Osamu and Ueda, Fumiaki and Nakada, Mitsutoshi},
 issue = {5},
 journal = {Pituitary},
 month = {Oct},
 note = {Purpose: Although hemorrhage within pituitary adenomas frequently exacerbates the symptoms, there are many grades of severity. Moreover, the contributing factors for symptom severity are still controversial. Methods: This retrospective study included 82 patients who underwent transsphenoidal surgery for pituitary adenomas with intratumoral hemorrhage. The grades of preoperative symptoms were classified into group A, asymptomatic or minor symptoms; group B, moderate symptoms sufficient for complain; and group C, severe symptoms disturbing daily life. Results: The hemorrhage volume within an adenoma was significantly higher in group C (92.6%) than in groups A (48.6%) and B (58.7%). Both headache and diplopia were dominant in group C, occurring in 72.2% and 27.8% of the patients, respectively. In group C, there was no significant difference in frequency between adenoma extensions into the sphenoid sinus (0%) and involvement of the cavernous sinus of Knosp grade 4 (0%), and extensions into the suprasellar region were not common (38.9%). The most distinctive feature was that “no extrasellar extension” was found only in group C (41.2%), and “multidirectional extension” was not detected in this group (0%). Multiple regression analysis revealed that the most powerful determining factors were the high frequencies of intratumoral hemorrhage and lack of extrasellar and multidirectional extensions. Conclusion: Rapid volume expansion of a hematoma and lack of extension or unidirectional extension might lead to significant compression of the sellar and surrounding structures. Of note, the integrity of the sellar dura might contribute to the acute onset of symptom manifestations caused by hemorrhage in pituitary adenomas. © 2017 Springer Science+Business Media, LLC, Embargo Period 12 months},
 pages = {531--538},
 title = {Contribution of sellar dura integrity to symptom manifestation in pituitary adenomas with intratumoral hemorrhage},
 volume = {20},
 year = {2017}
}