{"created":"2023-07-27T06:50:01.738682+00:00","id":42079,"links":{},"metadata":{"_buckets":{"deposit":"58665d8a-bb5c-46f5-97f1-a41c32cbd7e4"},"_deposit":{"created_by":3,"id":"42079","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"42079"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00042079","sets":["1132:1133:1135"]},"author_link":["65367","65363","65364","233","70676","70677","70675","65366","65365","36"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"24","bibliographicPageStart":"17","bibliographicVolumeNumber":"125","bibliographic_titles":[{"bibliographic_title":"Journal of Neural Transmission"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"東田, 陽博"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"堀, 修"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"辻, 知陽"}],"nameIdentifiers":[{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The role of cyclic ADP-ribose (cADPR) as a second messenger and modulator of the mTOR pathway downstream of dopamine (DA) receptors and/or CD38 was re-examined in the mouse. ADP-ribosyl activity was low in the membranes of neonates, but DA stimulated it via both D1- and D2-like receptors. ADP-ribosyl cyclase activity increased significantly during development in association with increased expression of CD38. The cADPR binding proteins, FKBP12 and FKBP12.6, were expressed in the adult mouse striatum. The ratio of phosphorylated to non-phosphorylated S6 kinase (S6K) in whole mouse striatum homogenates decreased after incubation of adult mouse striatum with extracellular cADPR for 5 min. This effect of cADPR was much weaker in MPTP-treated Parkinson’s disease model mice. The inhibitory effects of cADPR and rapamycin were identical. These data suggest that cADPR is an endogenous inhibitor of the mTOR signaling pathway downstream of DA receptors in the mouse striatum and that cADPR plays a certain role in the brain in psychiatric and neurodegenerative diseases. © 2016 Springer-Verlag Wien","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Embargo Period 12 months","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00042066","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer-Verlag"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00702-016-1666-7","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA10850492","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0300-9564","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Higashida, Haruhiro"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Kamimura, Shin-ya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inoue, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hori, Osamu"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Islam, Mohammad Saharul"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Lopatina, Olga"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuji, Chiharu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-01-02"}],"displaytype":"detail","filename":"CH-PR-HIGASHIDA-H-2016.pdf","filesize":[{"value":"453.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CH-PR-HIGASHIDA-H-17.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/42079/files/CH-PR-HIGASHIDA-H-2016.pdf"},"version_id":"112ebf9b-e21b-4f42-be99-c4117408471b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cyclic ADP-ribose as an endogenous inhibitor of the mTOR pathway downstream of dopamine receptors in the mouse striatum","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cyclic ADP-ribose as an endogenous inhibitor of the mTOR pathway downstream of dopamine receptors in the mouse striatum"}]},"item_type_id":"4","owner":"3","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-01-18"},"publish_date":"2018-01-18","publish_status":"0","recid":"42079","relation_version_is_last":true,"title":["Cyclic ADP-ribose as an endogenous inhibitor of the mTOR pathway downstream of dopamine receptors in the mouse striatum"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T17:42:58.242243+00:00"}