{"created":"2023-07-27T06:50:05.918418+00:00","id":42576,"links":{},"metadata":{"_buckets":{"deposit":"e3534b72-0303-4596-8953-6fe4c4369d90"},"_deposit":{"created_by":18,"id":"42576","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"42576"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00042576","sets":["2812:2813:2835"]},"author_link":["67955","67952"],"item_10007_biblio_info_24":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicPageStart":"2p.","bibliographicVolumeNumber":"1997-1998","bibliographic_titles":[{"bibliographic_title":"平成10(1998)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"1998 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"1999-03","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脳梗塞後の排尿反射亢進におけるグルタミン酸受容体の関与について検討するため以下の実験を行い結果を得た.\n1) NMDA受容体antagonistとしてMK801,AMPA/KA受容体antagonistとしてNBQXを用いた.ハロセン麻酔下,膀胱瘻を作成したSD種雄性ラットに対し,各薬剤を静注した後に中大脳動脈を閉塞して脳梗塞を作成,膀胱容量を覚醒下に経時的に測定した.\n2) MK801の静脈内投与では,覚醒下では膀胱容量の減少をウレタン麻酔下では膀胱容量の増大を認めた.偽手術では,ウレタン麻酔下,高用量のMK801が膀胱容量の増大を認めなかった.\n3) 脳梗塞前投与では,NMDA受容体のantagonist投与で最初減少した膀胱容量が時間経過と共に増大した.このことは脳梗塞による膀胱容量の減少を発生の段階で抑制したものと考えられた.\n4) 脳梗塞後,脳室内にカルシウム拮抗剤を投与すると,膀胱容量の増大が得られたが,最大膀胱収縮圧,残尿量に変化は認められなかった.偽手術ラットではこの効果は認められず,脳梗塞状態でカルシウム拮抗薬は中枢に作用して,排尿反射の亢進を抑制する効果があるものと考えられた.\n5) NMDA受容体の発現を抑制するために,脳梗塞作成前にアンチセンスを脳室内に投与したところ,脳梗塞後の膀胱容量の減少を発生段階で抑制する事ができた.\n6) 以上の結果から,NMDA受容体は脳梗塞後の膀胱容量の減少に関して重要な関与があり,これを修飾することで脳梗塞後の膀胱容量の減少を薬理学的に抑えるのみならず,遺伝治療にも応用可能と考えられた.","subitem_description_type":"Abstract"},{"subitem_description":"ROLE OF NMDA AND AMPA/KINATE RECEPTOR CHANNELS IN THE - PREVENTION OF BLADDER OVERACTIVITY AFTER CEREBRAL INFARCTION\nINTRODUCTION AND OBJECTIVES : To investigate the role of glutamatergic receptors in detrusor hyperreflexia after cerebrovascular disease, we examined the effect of two different types of glutamate receptor antagonists on bladder function after focal cerebral infarction in rat model.\nMETHODS : Focal cerebral infarction was produced with a middle cerebral artery occlusion (MCAO) technique on the left side in female S-D rats under halothane anesthesia. Cystometric examination was performed on unanesthetized rats through a catheter implanted in the dome of the urinary bladder. Entire experiments was designed to allow for observation of acute phase (0 to 8 hours) reaction after MCAO.Two kinds of glutamate receptor antagonists were administrated intravenously before or after MCAO.\nRESULTS : Bladder capacity of conscious rats was significantly reduced just after MCAO and remained comparatively small for 8 hours. Intravenous administration of N -methyl-d-aspartate (NMDA) receptor antagonist MK-801. (0.5 mg/kg) prior to MCAO prevented the reduction in bladder capacity. This effect becaome gradually observable about 4 hours after MCAO.The bladder capacity of rats given a-amino -3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)/kinate receptor antagonist NBQX (10, 30 mg/kg) prior to MCAO was not different from that of rats with vehicle administration followed by MCAO.Administration of MK-801(0.5 mg/kg) or NBQX (30 mg/kg) after MCAO did not inhibit the reduction in bladder capacity.\nCONCLUSIONS : Our results suggest that glutamate may play a part in the pathogenesis of voiding dysfunction after cerebrovascular disease, and that the NMDA receptor may play a more dominant role than the AMPA/kinate receptor in evoking bladder overactivity after MCAO.","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:09671619, 研究期間(年度):1997-1998","subitem_description_type":"Other"},{"subitem_description":"研究機関: 金沢大学医学部附属病院","subitem_description_type":"Other"},{"subitem_description":"出典：「脳卒中に伴う神経因性膀胱の成因解明および遺伝子治療に関する実験的研究」研究成果報告書　課題番号09671619\n  (KAKEN：科学研究費助成事業データベース（国立情報学研究所）)\n　　　本文データは著者版報告書より作成","subitem_description_type":"Other"}]},"item_10007_description_4":{"attribute_name":"研究代表者ID","attribute_value_mlt":[{"subitem_description":"80291368","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"09671619","subitem_description_type":"Other"}]},"item_10007_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00048931","subitem_identifier_reg_type":"JaLC"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80291368"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80291368","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671619/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671619/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-09671619/096716191998kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-09671619/096716191998kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-13"}],"displaytype":"detail","filename":"ME-PR-KOMATSU-K-kaken 1999-2p.pdf","filesize":[{"value":"252.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KOMATSU-K-kaken 1999-2p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/42576/files/ME-PR-KOMATSU-K-kaken 1999-2p.pdf"},"version_id":"dba9fcf6-dae5-426a-9dcc-2a9073eb6a5b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Stroke","subitem_subject_scheme":"Other"},{"subitem_subject":"neurogenic bladder","subitem_subject_scheme":"Other"},{"subitem_subject":"bladder overactivity","subitem_subject_scheme":"Other"},{"subitem_subject":"NMDA","subitem_subject_scheme":"Other"},{"subitem_subject":"antisense","subitem_subject_scheme":"Other"},{"subitem_subject":"glutamate","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小松, 和人"}],"nameIdentifiers":[{"nameIdentifier":"67955","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80291368","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80291368"}]},{"creatorNames":[{"creatorName":"Komatsu, Kazuto"}],"nameIdentifiers":[{"nameIdentifier":"67952","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80291368","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80291368"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脳卒中に伴う神経因性膀胱の成因解明および遺伝子治療に関する実験的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脳卒中に伴う神経因性膀胱の成因解明および遺伝子治療に関する実験的研究"},{"subitem_title":"Role of NMDA and ampa/kinate receptor channels in the prevention of bladder overactivity after cerebral infarction","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"18","path":["2835"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-13"},"publish_date":"2017-11-13","publish_status":"0","recid":"42576","relation_version_is_last":true,"title":["脳卒中に伴う神経因性膀胱の成因解明および遺伝子治療に関する実験的研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:48:47.683553+00:00"}