{"created":"2023-07-27T06:50:06.993342+00:00","id":42600,"links":{},"metadata":{"_buckets":{"deposit":"b8026c15-df9b-4fd3-99c0-d94fabaa84e6"},"_deposit":{"created_by":18,"id":"42600","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"42600"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00042600","sets":["2812:2813:2823"]},"author_link":["68003","68002"],"item_10007_biblio_info_24":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-05-19","subitem_date_issued_type":"Issued"}]},"item_10007_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"マウス顎下腺の導管系は著しい性差をもち、顆粒性導管(GCT)が雄においてのみ発達するが、その分子メカニズムは明らかでない。本研究では、マウス顎下腺の線条部導管細胞がアンドロゲンによりGCT細胞に分化する際、JunDやCREBなど、細胞膜受容体の下流で働く転写因子が核から消失することが明らかになり、顎下腺導管系の分化においてアンドロゲン受容体と他の転写因子との間の特別な相互作用が関与することが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"The duct system of mouse submandibular gland has a pronounced sexual dimorphism, in which granular convoluted tubules (GCT) are developed preferentially in males, but its molecular mechanisms are unclear. The present study has revealed that JunD and CREB, which belong to the transcription factors functioning downstream of transmembrane receptors, disappear from the nuclei as a result of androgen-induced differentiation of GCT cells from striated duct cells. These results suggest that a special kind of cross-talk between the androgen receptor and other transcription factors is involved in the differentiation of the submandibular duct system.","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20590187, 研究期間(年度):2008-2010","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「顎下腺の分化におけるアンドロゲンの作用機序の研究」課題番号20590187\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590187/20590187seika/）を加工して作成","subitem_description_type":"Other"}]},"item_10007_description_4":{"attribute_name":"研究代表者ID","attribute_value_mlt":[{"subitem_description":"50167251","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"20590187","subitem_description_type":"Other"}]},"item_10007_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00048955","subitem_identifier_reg_type":"JaLC"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50167251"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50167251","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590187/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590187/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590187/20590187seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590187/20590187seika/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-16"}],"displaytype":"detail","filename":"ME-PR-ISEKI-S-kaken 2011-4p.pdf","filesize":[{"value":"176.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-ISEKI-S-kaken 2011-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/42600/files/ME-PR-ISEKI-S-kaken 2011-4p.pdf"},"version_id":"3657d610-6b27-47e0-ad21-46c1e243d2a2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"細胞分化","subitem_subject_scheme":"Other"},{"subitem_subject":"組織形成","subitem_subject_scheme":"Other"},{"subitem_subject":"顎下腺","subitem_subject_scheme":"Other"},{"subitem_subject":"導管系","subitem_subject_scheme":"Other"},{"subitem_subject":"顆粒性導管","subitem_subject_scheme":"Other"},{"subitem_subject":"アンドロゲン","subitem_subject_scheme":"Other"},{"subitem_subject":"転写因子","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井関, 尚一"}],"nameIdentifiers":[{"nameIdentifier":"68003","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50167251","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50167251"}]},{"creatorNames":[{"creatorName":"Iseki, Shoichi"}],"nameIdentifiers":[{"nameIdentifier":"68002","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50167251","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50167251"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"顎下腺の分化におけるアンドロゲンの作用機序の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"顎下腺の分化におけるアンドロゲンの作用機序の研究"},{"subitem_title":"Study on the functional mechanisms of androgens in differentiation of the mouse submandibular gland","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-16"},"publish_date":"2017-11-16","publish_status":"0","recid":"42600","relation_version_is_last":true,"title":["顎下腺の分化におけるアンドロゲンの作用機序の研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:18:33.835086+00:00"}