{"created":"2023-07-27T06:50:07.082204+00:00","id":42602,"links":{},"metadata":{"_buckets":{"deposit":"ca0b58d5-04ba-4bb9-92fb-9a8bbf992c90"},"_deposit":{"created_by":18,"id":"42602","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"42602"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00042602","sets":["2812:2813:2829"]},"author_link":["68002","68007"],"item_10007_biblio_info_24":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicPageStart":"7p.","bibliographicVolumeNumber":"2003-2004","bibliographic_titles":[{"bibliographic_title":"平成16(2004)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2004 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2005-05","subitem_date_issued_type":"Issued"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"齧歯類の顎下腺の分化におけるシグナル伝達について研究し、次の結果を得た。1)マウス顎下腺において、転写因子であるJunDの核内発現が導管系に局在し、雄より雌マウスで高いこと、雌マウスへのテストステロン投与により線状部導管細胞が顆粒性導管細胞へ分化する際にJunD発現が一過性に上昇した後に消失することから、導管系の分化にJunDが関与することがわかった(論文1)。2)JunDに結合してその転写誘導活性を調節するとされる核内蛋白質であるメニンのマウス顎下腺における発現のパターンがJunDの発現パターンと一致し、JunDとメニンの結合体がアンドロゲンによる顎下腺分化機構に関与することが示唆された(論文準備中)。3)腺房細胞における蛋白分解酵素阻害物質であるシスタチンS(CysS)の発現は、イソプロテレノール(IPR)の投与により誘導されるが、下垂体切除ラットの顎下腺ではIPRによるCysSの発現誘導が著明に低下していること、これにテストステロン、エストロゲンなどのステロイドホルモンを投与すると誘導が著明に回復することが分かり、腺房の分化が神経と下垂体の2重支配を受けることがわかった(論文2)。これらの研究結果から、齧歯類の顎下腺の分化においてアンドロゲンその他の因子による様々な細胞内シグナル伝達系の相互関係(クロストーク)が関与することが示唆された。4)ラット舌下腺のみに特異的に発現する動物レクチンをクローニングし、SLAMP(舌下腺腺房膜蛋白質)と名付けた。免疫抗体を作成してラット舌下腺を調べたところ、腺房細胞の粗面小胞体とゴルジ装置の中間領域(ERGIC)の膜に局在することがわかり、SLAMPが舌下腺腺房細胞によるムチンなどの糖蛋白質の初期分泌過程に関与していることが示唆された(論文3)。","subitem_description_type":"Abstract"},{"subitem_description":"In regard to the differentiation of rodent submandibular glands (SMG), we have obtained the following results :\n1)In the mouse SMG, the expression of the transcription factor JunD is localized to the duct system and much more abundant in the female than in the male gland. During the postnatal development and testosterone-induced GCT cell differentiation, JunD expression is temporarily induced in the nuclei of striated duct cells and dispappeares as they differentiated into GCT cells (Reference 1).\n2)The expression and localization of menin, a nuclear protein that binds JunD, showed the same pattern in the mouse SMG as that of JunD, suggesting that JunD-menin complex is responsible for the duct differentiation.\n3)In the SMG of hypophysectomized rats, the induction of the protease inhibitor cystatin S by the b-adrenergic agonist isoproterenol is much less than that in the control. Administration of one of the pituitary-dependent hormones, i.e., testosterone, estradiol, dexamethasone and thyroxine, together with isoproterenol results in marked recovery of cystatin S expression (Reference 2).\nThese results suggest the role of cross-talks between multiple signaling pathways, including that of androgens, in the differentiation of rodent SMG.\n4)We have cloned a novel animal lectin specifically expressed in the rat sublingual gland and named it STAMP (sublingual gland acinar membrane protein). SLAMP is localized to the membrane of ER-Golgi intermediate compartment (ERGIC), suggesting its role in the early secretory pathway of mucin glycoproteins.","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15590156, 研究期間(年度):2003-2004","subitem_description_type":"Other"},{"subitem_description":"出典：「顎下腺導管系のアンドロゲンによる分化機構の研究」研究成果報告書　課題番号15590156\n(KAKEN：科学研究費助成事業データベース（国立情報学研究所）)\n　　　本文データは著者版報告書より作成","subitem_description_type":"Other"}]},"item_10007_description_4":{"attribute_name":"研究代表者ID","attribute_value_mlt":[{"subitem_description":"50167251","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"15590156","subitem_description_type":"Other"}]},"item_10007_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00048957","subitem_identifier_reg_type":"JaLC"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50167251"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50167251","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15590156/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15590156/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15590156/155901562004kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15590156/155901562004kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-16"}],"displaytype":"detail","filename":"ME-PR-ISEKI-S-kaken 2005-7p.pdf","filesize":[{"value":"257.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-ISEKI-S-kaken 2005-7p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/42602/files/ME-PR-ISEKI-S-kaken 2005-7p.pdf"},"version_id":"42d9904a-97a0-41f5-9f78-4d51849aca50"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"顎下腺","subitem_subject_scheme":"Other"},{"subitem_subject":"発生と分化","subitem_subject_scheme":"Other"},{"subitem_subject":"シグナル伝達","subitem_subject_scheme":"Other"},{"subitem_subject":"転写因子","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子発現","subitem_subject_scheme":"Other"},{"subitem_subject":"分泌","subitem_subject_scheme":"Other"},{"subitem_subject":"アンドロゲン","subitem_subject_scheme":"Other"},{"subitem_subject":"レクチン","subitem_subject_scheme":"Other"},{"subitem_subject":"Submandibular gland","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Development and Differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Signal transduction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Transcription factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Gene expression","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Secretion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Androgen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lectin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"井関, 尚一"}],"nameIdentifiers":[{"nameIdentifier":"68007","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50167251","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50167251"}]},{"creatorNames":[{"creatorName":"Iseki, Shoichi"}],"nameIdentifiers":[{"nameIdentifier":"68002","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50167251","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50167251"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"顎下腺導管系のアンドロゲンによる分化機構の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"顎下腺導管系のアンドロゲンによる分化機構の研究"},{"subitem_title":"The mechanism of androgen-dependent differentiation of the duct system in the submandibular gland","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"18","path":["2829"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-16"},"publish_date":"2017-11-16","publish_status":"0","recid":"42602","relation_version_is_last":true,"title":["顎下腺導管系のアンドロゲンによる分化機構の研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:29:27.523817+00:00"}