{"created":"2023-07-27T06:50:07.443379+00:00","id":42610,"links":{},"metadata":{"_buckets":{"deposit":"a12e09a7-7ab8-478f-b83b-b2561c35346d"},"_deposit":{"created_by":18,"id":"42610","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"42610"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00042610","sets":["2812:2813:2823"]},"author_link":["2472","20454"],"item_10007_biblio_info_24":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-04-04","subitem_date_issued_type":"Issued"}]},"item_10007_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1.前立腺癌の再燃に関与する因子として重要なものに副腎性アンドロゲンDHEAがあるが、これは、前立腺がん組織において癌細胞と間質細胞の協調的働きによりDHTに変換され、前立腺癌の再増殖に寄与することを証明した。2.前立腺癌の骨転移に関しては骨由来TGF-βの作用が重要で、抗アレルギー薬であるトラニラストが、その作用を抑制し、抗腫瘍効果をもたらす可能性があることを示した。3.再燃前立腺癌に対してはタキサン系抗癌剤を使用することが多いが、その薬剤に対する耐性メカニズムのひとつにCTENの発現低下が関与していることを証明した。","subitem_description_type":"Abstract"},{"subitem_description":"1. Adrenal androgen, DHEA, is important for recurrence of prostate cancer. Prostate cancer stromal cells and prostate cancer cells coordinately activate the androgen receptor through synthesis of T and DHT from DHEA. 2. Tranilast inhibits hormone refractory prostate cancer cell proliferation and suppresses TGF-β-associated osteoblastic changes. 3. We identified CTEN, one of important genes that is associated with paclitaxel resistance. Expression of CTEN recovered paclitacel-resistance.","subitem_description_type":"Abstract"}]},"item_10007_description_14":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20390421, 研究期間(年度):2008-2010","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「前立腺癌再燃の分子機序解明とその治療戦略構築のための基礎的研究」課題番号20390421\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20390421/20390421seika/）を加工して作成","subitem_description_type":"Other"}]},"item_10007_description_4":{"attribute_name":"研究代表者ID","attribute_value_mlt":[{"subitem_description":"70155985","subitem_description_type":"Other"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"2039042","subitem_description_type":"Other"}]},"item_10007_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00048965","subitem_identifier_reg_type":"JaLC"}]},"item_10007_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70155985"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70155985","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390421/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390421/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20390421/20390421seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20390421/20390421seika/","subitem_relation_type_select":"URI"}}]},"item_10007_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-16"}],"displaytype":"detail","filename":"ME-PR-NAMIKI-M-kaken 2011-5p.pdf","filesize":[{"value":"223.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-NAMIKI-M-kaken 2011-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/42610/files/ME-PR-NAMIKI-M-kaken 2011-5p.pdf"},"version_id":"eb062205-c3ab-48e3-9764-c8cc33ada378"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"前立腺癌","subitem_subject_scheme":"Other"},{"subitem_subject":"DHEA","subitem_subject_scheme":"Other"},{"subitem_subject":"間質細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"トラニラスト","subitem_subject_scheme":"Other"},{"subitem_subject":"CTEN","subitem_subject_scheme":"Other"},{"subitem_subject":"パクリタキセル耐性","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"並木, 幹夫"}],"nameIdentifiers":[{"nameIdentifier":"2472","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70155985","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70155985"}]},{"creatorNames":[{"creatorName":"Namiki, Mikio"}],"nameIdentifiers":[{"nameIdentifier":"20454","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70155985","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70155985"},{"nameIdentifier":"70155985","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000070155985"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"前立腺癌再燃の分子機序解明とその治療戦略構築のための基礎的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"前立腺癌再燃の分子機序解明とその治療戦略構築のための基礎的研究"},{"subitem_title":"The basic research for elucidation of molecular mechanism of the prostate cancer recurrence and the treatment strategy construction","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-16"},"publish_date":"2017-11-16","publish_status":"0","recid":"42610","relation_version_is_last":true,"title":["前立腺癌再燃の分子機序解明とその治療戦略構築のための基礎的研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T06:00:28.597616+00:00"}