{"created":"2023-07-27T06:50:13.218878+00:00","id":42916,"links":{},"metadata":{"_buckets":{"deposit":"3a81726b-ef24-4351-92bd-c5473d90a032"},"_deposit":{"created_by":18,"id":"42916","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"42916"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00042916","sets":["2812:2813:2823"]},"author_link":["204","68634"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-19","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究において、4つの原子核プローブ法に注目し、脳・神経内微量遷移金属の局在性について知見を得た。特に、「重元素Tl(タリウム)がBBBを経由することなく脳内に直接に移行すること」を見出し、鼻腔を経由する金属元素の脳内移行についてのさらに広い知見を得て、^<201>TlClの人体応用の道を拓いた。MRI法のMnとGdの造影効果を利用し、Mnについては脳内最低検出濃度について、GdについてはGd DTPAの腎内を用いて検討した。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, several information and data on the in-vivo-localization of transition metal in brain were obtained by the use of four different nuclear probe detection methods. Especially, using RI technique, we found that trace heavy Tl ion transfers directly from nose to brain bypassing BBB. Intranasal administration of other metal ions was also examined by multi-tracer method. On the bases of results, the usefulness of ^<201>TlCl in rhinological fields was proposed to our other related projects. In correlation of metal imaging and MRI technique, we examined the detection of Mn in brain and behavior of Gd-DTPA in kidney.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20550059, 研究期間(年度):2008-2010","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「原子核プローブ法による遷移金属の脳・神経における局在性に関する生物無機化学の研究」課題番号20550059\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20550059/20550059seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域保健学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00049265","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30111769"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30111769","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20550059/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20550059/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20550059/20550059seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20550059/20550059seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-08"}],"displaytype":"detail","filename":"ME-PR-AMANO-R-kaken 2011-5p.pdf","filesize":[{"value":"456.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-AMANO-R-kaken 2011-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/42916/files/ME-PR-AMANO-R-kaken 2011-5p.pdf"},"version_id":"99cea6cc-7c19-4203-8b9d-7c2e2a321b93"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"原子核プローブ法による遷移金属の脳・神経における局在性に関する生物無機化学の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"原子核プローブ法による遷移金属の脳・神経における局在性に関する生物無機化学の研究"},{"subitem_title":"Bioinorganic study of transition metal localization in brain by the use of nuclear probe detection method","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-08"},"publish_date":"2017-12-08","publish_status":"0","recid":"42916","relation_version_is_last":true,"title":["原子核プローブ法による遷移金属の脳・神経における局在性に関する生物無機化学の研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:18:32.663702+00:00"}