{"created":"2023-07-27T06:50:13.445142+00:00","id":42921,"links":{},"metadata":{"_buckets":{"deposit":"70046b32-f72a-4175-98d3-257966021ac0"},"_deposit":{"created_by":18,"id":"42921","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"42921"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00042921","sets":["2812:2813:2819"]},"author_link":["68639","68640"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-04","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2012-04-01 – 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脳梗塞後の小胞体ストレス応答(UPR)の重要性を明らかにする為、UPRの主幹転写因子ATF6αを欠損したATF6α KOマウスを用いて中大脳動脈閉塞モデルを作製した。その結果、野生型（WT）マウスに比し脳梗塞巣の拡大を認め、その原因として、アストロサイト活性化の低下、及びグリア瘢痕の低形成による組織障害の拡大が示唆された。更に培養アストロサイトを用いた解析から、ATF6α KOアストロサイトではSTAT3-GFAP経路の活性化が低下していることが明らかになった。本研究により、脳虚血後のアストロサイト活性化、グリア瘢痕形成、そして神経保護にUPRが重要であることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"To dissect the role of the unfolded protein response (UPR) in brain ischemia, we investigated the relevance of ATF6α, a master transcriptional factor in the UPR, after middle cerebral artery occlusion (MCAO) in mice. Enhanced expression of GRP78, a downstream molecular chaperone of ATF6α, was observed in the peri-infarct region of wild-type mice after MCAO. Analysis using wild-type and Atf6α-/- mice revealed a larger infarct volume and increased cell death in the peri-ischemic region of Atf6α-/- mice 5 days after MCAO. These phenotypes in Atf6α-/- mice were associated with reduced levels of astroglial activation/glial scar formation, and a spread of tissue damage into the non-infarct area. Further analysis in mice and cultured astrocytes revealed that STAT3-GFAP signaling was diminished in Atf6α-/- astrocytes. These results suggest a critical role of the UPR for regulating astroglial activation and neuronal survival after brain ischemia.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24500419, 研究期間(年度):2012-04-01 – 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ATF6及びATF4による虚血性神経細胞死の阻止」課題番号24500419\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24500419/24500419seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00049270","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00019613"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00019613","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24500419/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24500419/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24500419/24500419seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24500419/24500419seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-08"}],"displaytype":"detail","filename":"ME-PR-KITAO-Y-kaken 2015-5p.pdf","filesize":[{"value":"472.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KITAO-Y-kaken 2015-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/42921/files/ME-PR-KITAO-Y-kaken 2015-5p.pdf"},"version_id":"6bf761cd-08a8-443e-a8f1-890fdf0f6a92"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ATF6及びATF4による虚血性神経細胞死の阻止","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ATF6及びATF4による虚血性神経細胞死の阻止"},{"subitem_title":"Protective roles of ATF6 and ATF4 in the mouse model of stroke","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-08"},"publish_date":"2017-12-08","publish_status":"0","recid":"42921","relation_version_is_last":true,"title":["ATF6及びATF4による虚血性神経細胞死の阻止"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:45:24.537396+00:00"}