{"created":"2023-07-27T06:50:13.890496+00:00","id":42932,"links":{},"metadata":{"_buckets":{"deposit":"a89124fa-6c6f-48de-adbd-24bf6054e7dc"},"_deposit":{"created_by":18,"id":"42932","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"42932"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00042932","sets":["2812:2813:2838"]},"author_link":["20266","68650"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"18p.","bibliographicVolumeNumber":"1994-1995","bibliographic_titles":[{"bibliographic_title":"平成7(1995)年度 科学研究費補助金 一般研究(C) 研究成果報告書"},{"bibliographic_title":"1995 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"動脈硬化症の成因および進展にリポ蛋白代謝異常の重要性が指摘されている。今回は、我々が世界で初めて報告したCETP遺伝子異常をさらに検討し、新しいエキソン15のミスセンス変異を明らかにした。また、食後レムナント代謝異常が存在する糖尿病患者と家族性複合型高脂血症(FCHL)の関係の検討のために、家族調査により診断されたFCHLの耐糖能異常を検討した。CETP遺伝子異常の検討で、Int14Aのホモ接合体は15例、ヘテロ接合体は12例、D442Gのホモ接合体は4例、ヘテロ接合体は35例が明らかにされた。一般男性でのCETP遺伝子異常の頻度はInt14Aのヘテロが2%、D442Gのヘテロが7%と高頻度に認められ、CETP遺伝子異常が日本人のリポ蛋白代謝へ大きく影響を及ぼしていると考えられた。FCHLの頻度の検討では、49例中14例(29%)がFCHLであった。高脂血症を合併する糖尿病患者の50%がFCHLであった。さらに、FCHLでは耐糖能障害が多く認められ、75g0GTTによるIRI濃度時間曲線下面積(AUC-IRI)の平均は、FCHL群のN群とIGT群ではC群のN群とIGT群より有意に高値であった(p〈0.05)。さらに、FCHL群のN群とIGT群のAUC-IRI/AUC-血糖比は、C群のN群とIGT群より有意に高値であった(p〈0.05)。FCHLのN群のHDL-CはC群より有意に低値であり、IRI反応とIDL-C、HDL-C、TGとの関係では、FCHL群ではIDL-CとAUC-IRIとの間に有意な正相関が認められた(p〈0.05)。糖尿病患者の血清CETP活性は正常コントロールと有意差は認められなかった。以上より、高脂血症を伴う糖尿病患者ではFCHL合併が高頻度に示唆され、さらに、FCHLにおける高インスリン血症が明らかとなった。今後さらにレムナント代謝とCETPの関係を、動脈硬化を生じるリポ蛋白代謝異常の解明のために検討しなければならない。","subitem_description_type":"Abstract"},{"subitem_description":"Cholesteryl ester transfer protein (CETP) mediates the heteroexchange of HDL cholesteryl esters with triglycerides of VLDL and chylomicrons. The impaired triglyceride-rich lipoprotein metabolism and accumulaton of remnant lipoproteins, has been reported in diabetic or familial combined hyperlipidemic patiens. The increased CETP activity may produce atherogenic lipid compositions of apoprotein-B-containing lipoproteins, as a result of cholesterol transport from HDL.To study a role of CETP in the impaired remnant metabolism, the CETP gene mutations were searched in Japanese people, and the insulin resposes after glucose administration in FCHL patients were examined.\nTwo novel mutations were identified : an intron 14 splice donor site mutation caused by a T insertion at position +3 (Int14 T) and a missense mutation (Asp442 to Gly) within exon 15 (D442G), in addition to an intron 14G (+1) to A mutaion (Int14 A) which was previously reported. Prevalences of the D442G and Int14 A mutations were extremely high in the general sample of Japanese men (n=236), with heterozygote frequencies of 7% and 2%, respectively.\nAccording to the 75gOGTT,35% of FCHL patients showed an impaired glucose tolerance and 25% of FCHL patients a diabetic glucose tolerance. Area under the plasma insulin concentration-time curve in the FCHL patients with normal and impaired glucose tolerances were significant higher than those in the control group (p<0.05). There were significant relationships between AUC-IRI and LDL-cholesterol levels (p<0.05). FCHL and hyperinsulinemia in diabetic patients, may be important factors linkaging diabetes and CHD.\nIn conclusion, FCHL patients showed hyperinsulinemia after glucose administration, and may contribute to the increased CHD in the patients with glucose intolerance. CETP may play a role in the impaired remnant metabolism in FCHL and diabetic patients. Further study will be required.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:06671013, 研究期間(年度):1994-1995","subitem_description_type":"Other"},{"subitem_description":"出典：「食後レムナント代謝異常におけるコレステリルエステル転送蛋白の役割」研究成果報告書　課題番号06671013\n(KAKEN：科学研究費助成事業データベース（国立情報学研究所）)\n　　　本文データは著者版報告書より作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00049281","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医学部附属病院"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20161846"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20161846","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06671013/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06671013/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-06671013/066710131995kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-06671013/066710131995kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-09"}],"displaytype":"detail","filename":"ME-PR-KOIZUMI-J-kaken 1996-18p.pdf","filesize":[{"value":"459.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-KOIZUMI-J-kaken 1996-18p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/42932/files/ME-PR-KOIZUMI-J-kaken 1996-18p.pdf"},"version_id":"a25f5c82-29a8-4cd3-9696-7a4cc4646ae6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"食後レムナント代謝異常におけるコレステリルエステル転送蛋白の役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"食後レムナント代謝異常におけるコレステリルエステル転送蛋白の役割"},{"subitem_title":"A role of cholestoryl ester transfer protin in postprandial remnant lipoprotein metabolism","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2838"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-07"},"publish_date":"2017-12-07","publish_status":"0","recid":"42932","relation_version_is_last":true,"title":["食後レムナント代謝異常におけるコレステリルエステル転送蛋白の役割"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:54:14.884019+00:00"}