{"created":"2023-07-27T06:50:18.375759+00:00","id":43036,"links":{},"metadata":{"_buckets":{"deposit":"e8d75acc-a1d4-4ea5-bd4c-c75650922adb"},"_deposit":{"created_by":17,"id":"43036","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"43036"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043036","sets":["1132:1133:1134"]},"author_link":["69242","69246","69248","69245","69240","120","69247","69244","69241","69249","69243","69239","13188"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicVolumeNumber":"261","bibliographic_titles":[{"bibliographic_title":"Radiology"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大野, 直樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宮地, 利明"}],"nameIdentifiers":[{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Normal-pressure hydrocephalus (NPH) is characterized by a clinical triad of ataxia, incontinence, and dementia, as well as dilated ventricles but normal cerebrospinal fluid (CSF) pressures. In patients with NPH, CSF shunt placement is effective for improving these symptoms (1). NPH has attracted attention as one of the few treatable causes of dementia. Diagnosis of idiopathic NPH (INPH) without a known cause of communicating hydrocephalus, including subarachnoid hemorrhage or meningitis, is particularly difficult (2). Moreover, to clarify the cause of NPH, accurately diagnose NPH, and identify appropriate patients for shunt surgery, several tests have been proposed, including cisternography, the CSF tap test, resistance measures, external lumbar drainage, and intracranial pressure recording, in addition to clinical findings and conventional imaging diagnosis with x-ray computed tomography or magnetic resonance (MR) imaging (3–6). It has also been reported (7) that a single standard for the prognostic evaluation of patients with INPH was lacking and that supplemental tests could increase the predictive accuracy of the prognosis. The CSF tap test is a particularly reliable examination, but it is invasive and has low sensitivity. It has been proposed that MR imaging CSF flow studies can be used to noninvasively obtain information about intracranial mechanical properties in INPH (eg, intracranial compliance) (2,8–12). However, the diagnostic utility of this latter method is still not established.\n\nArterial inflow into the cranium induces venous and CSF outflow and displacement of the intracranial spinal cord during the cardiac cycle, resulting in pulsatile brain motion (12–14). Brain pulsation (ie, bulk motion) reportedly can give rise to artifactual phase dispersion and may lead to overestimation of the apparent diffusion coefficient (ADC) (15,16). Brockstedt et al (17) reported that ADC was not changed significantly during the cardiac cycle with the single-shot echo-planar imaging (EPI) sequence widely used in diffusion MR imaging. However, they analyzed only two delay times (100 and 400 msec) between the R peaks in the cardiac cycle. To more completely analyze ADC changes during the cardiac cycle, our own group has previously evaluated the temporal change in ADC during the entire cardiac cycle by using an electrocardiographically (ECG)-triggered single-shot diffusion EPI sequence to minimize bulk motion effect. As a result, we revealed in a previous study that white matter ADC changed significantly over the cardiac cycle and that such changes were synchronized with the arterial inflow (volume loading) at systole (18). We further hypothesize that changes in ADC during the cardiac cycle are related to the biomechanical properties of intracranial tissues; hence, observed temporal changes in ADC in diseases such as INPH that are characterized by low intracranial compliance (12) may well be different than those in other diseases. Therefore, the purpose of our study was to determine whether temporal changes in ADC over the cardiac cycle were different in patients with INPH as compared with patients with ex vacuo ventricular dilatation and healthy control subjects.\n","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Radiological Society of North America"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1148/radiol.11101860","subitem_relation_type_select":"DOI"}}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohno, Naoki"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Miyati, Toshiaki"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Mase, Mitsuhito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osawa, Tomoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kan, Hirohito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kasai, Harumasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara, Masaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibamoto, Yuta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashi, Norio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Gabata, Toshifumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsui, Osamu"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-12"}],"displaytype":"detail","filename":"ME-PR-OHNO-N-197.pdf","filesize":[{"value":"259.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-OHNO-N-197","url":"https://kanazawa-u.repo.nii.ac.jp/record/43036/files/ME-PR-OHNO-N-197.pdf"},"version_id":"14ba14a0-a4a3-4c95-b1ec-89da0fc83865"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Idiopathic Normal-Pressure Hydrocephalus: Temporal Changes in ADC during Cardiac Cycle","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Idiopathic Normal-Pressure Hydrocephalus: Temporal Changes in ADC during Cardiac Cycle"}]},"item_type_id":"4","owner":"17","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-12"},"publish_date":"2017-12-12","publish_status":"0","recid":"43036","relation_version_is_last":true,"title":["Idiopathic Normal-Pressure Hydrocephalus: Temporal Changes in ADC during Cardiac Cycle"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-07-27T17:44:53.932354+00:00"}