{"created":"2023-07-27T06:50:19.138446+00:00","id":43053,"links":{},"metadata":{"_buckets":{"deposit":"ade8f061-56cf-4fc4-b3d5-b64ea1bf0f2d"},"_deposit":{"created_by":18,"id":"43053","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43053"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043053","sets":["2812:2813:2818"]},"author_link":["116","69263"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2013-04-01 – 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2005)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肝癌のGd-EOB-DTPA造影MRI肝細胞相における信号増強率は肝癌細胞におけるOATP1B3発現量に比例して有意に増加することを明らかにし、癌細胞におけるOATP1B3発現の間接的な分子イメージングであることを示した。また、OATP1B3の発現は転写因子HNF4αやb-cataninによって制御されている可能性が高いことを明らかにした。この結果から、肝癌のsubtypeを画像所見で認定することが可能となり、臨床の現場での個別化医療に貢献が期待される。","subitem_description_type":"Abstract"},{"subitem_description":"The significant positive correlation between grades of OATP1B3 expression and enhancement ratio on hepatobiliary phase of Gd-EOB-DTPA enhanced MR imaging in hepatocellular carcinoma (HCC) was verified in this study. In addition, the highly significant correlation between HNF4a, b-catenin and OATP1B3 expression in HCC cells was also revealed. These results made it possible to sub-classify HCCs, resulting in possible application for future personalized medicine in the patient s with HCCs easily in daily practice.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25461805, 研究期間(年度):2013-04-01 – 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「肝細胞癌の分子病理学的バイオマーカーと画像所見の関連に関する研究」課題番号25461805\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461805/25461805seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健学総合研究科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00049400","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10019961"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10019961","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461805/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461805/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461805/25461805seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25461805/25461805seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-21"}],"displaytype":"detail","filename":"ME-PR-MATSUI-O-kaken 2016-6p.pdf","filesize":[{"value":"96.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MATSUI-O-kaken 2016-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43053/files/ME-PR-MATSUI-O-kaken 2016-6p.pdf"},"version_id":"c79bfb85-d450-416b-9dc1-1646f6383e87"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝細胞癌の分子病理学的バイオマーカーと画像所見の関連に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝細胞癌の分子病理学的バイオマーカーと画像所見の関連に関する研究"},{"subitem_title":"Correlation between molecular biomarker and imaging findings in hepatocellular carcinoma","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-21"},"publish_date":"2017-12-21","publish_status":"0","recid":"43053","relation_version_is_last":true,"title":["肝細胞癌の分子病理学的バイオマーカーと画像所見の関連に関する研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:57:25.857980+00:00"}