{"created":"2023-07-27T06:50:19.183611+00:00","id":43054,"links":{},"metadata":{"_buckets":{"deposit":"334ec77a-11b0-4471-aed8-5b430eb2837b"},"_deposit":{"created_by":18,"id":"43054","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43054"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043054","sets":["2812:2813:2822"]},"author_link":["116","69263"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-14","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肝癌の多段階発癌にともない流出血流が肝静脈から門脈に変化し、これらがダイナミックCTでの悪性度診断に有用であることを明かにした。また、肝癌におけるOATP8の発現がGd-EOB-DTPA造影MRI(EOB-MRI)所見を規定すること、それが多段階発癌にともなって減少することを明らかにした。その結果EOB-MRIが早期肝癌の診断に極めて有用であることを示した。また、EOB-MRI肝細胞相で高信号を示す肝癌は悪性度の低いsubtypeであることを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"In accordance with the progression of multi-step hepatocarcinogenesis, the drainage vessels from the tumor changed from hepatic vein to hepatic sinusoids, and then portal vein, and this can be diagnosed by dynamic CT. There was an intensely significant correlation between OATP8 expression and signal intensity on hepatobiliary phase of Gd-EOB-DTPA enhanced MRI. In addition, the expression of OATP8 was decreased from very early stage of hepatocarcinogenesis in accordance with the elevation of grade of malignancy of the tumors. Therefore, EOB-MRI was proved to be extremely useful in the diagnosis of early HCC.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「肝細胞癌多段階発癌の画像診断に関する臨床的・基礎的研究」課題番号21591549\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21591549/21591549seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00049401","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10019961"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10019961","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591549/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591549/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21591549/21591549seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21591549/21591549seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-21"}],"displaytype":"detail","filename":"ME-PR-MATSUI-O-kaken 2012-5p.pdf","filesize":[{"value":"228.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MATSUI-O-kaken 2012-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43054/files/ME-PR-MATSUI-O-kaken 2012-5p.pdf"},"version_id":"da40001a-7255-4fba-b6d5-e343703a180f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝細胞癌多段階発癌の画像診断に関する臨床的・基礎的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝細胞癌多段階発癌の画像診断に関する臨床的・基礎的研究"},{"subitem_title":"Imaging diagnosis of multi-step hepatocarcinogenesis: clinical and basic analysis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-21"},"publish_date":"2017-12-21","publish_status":"0","recid":"43054","relation_version_is_last":true,"title":["肝細胞癌多段階発癌の画像診断に関する臨床的・基礎的研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:29:10.664579+00:00"}