{"created":"2023-07-27T06:50:19.229864+00:00","id":43055,"links":{},"metadata":{"_buckets":{"deposit":"5060d1e0-15c8-4ed0-8943-36080e57a150"},"_deposit":{"created_by":18,"id":"43055","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43055"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043055","sets":["2812:2813:2826"]},"author_link":["69262","20825"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-04","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"18p.","bibliographicVolumeNumber":"2006-2007","bibliographic_titles":[{"bibliographic_title":"平成19(2007)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2007 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"肝細胞癌(肝癌)は肝硬変を基盤として多段階的に発生することが多い。この過程での血管新生抑制は肝癌の発生や進展を抑制することが期待される。実験的転移性肝癌に対するサリドマイドによる抗血管新生効果についての生体顕微鏡によるin vivo研究を行った。その結果、サリドマイドは微小な肝転移形成期に腫瘍血管新生を阻害しその発達を抑制することが確認されが、腫瘍血管の形態や抑制時期はその発育段階でことなることが示唆された。臨床例でVEGFとその関連分子の発現(angiogenesis)と前癌病変の悪性転化の関連を免疫組織化学的に検討した。前癌病変と考えられるdysplastic nodule(DN)における毛細血管化した領域と異常筋性血管の増加は、DNの早期の悪性転化を表すものであると考えられ、これらの領域においてVEGF、Flk-1、HIF-1αの発現レベルが上昇することが、類洞毛細血管化や異常筋性血管数の増加に関与していると考えられた。すなわち、人肝癌ではDN内に血管新生因子による新生血管誘導が部分的に生じそれが全体的な悪性化に進展する過程が考えられた。肝細胞癌に対する肝動脈塞栓療法への血管新生抑制因子の応用の基礎的検討を目的として、血管新生因子であるbFGF含有ハイドロゲル粒子を作成し、肝内直接注入による血管新生誘導の可能性を検討した。これをrat肝内に直接開腹下に18G針で注入し局所の血管新生の有無を検討したが明らかな変化は認められなかった。今後技術的検討を継続する。血管新生がDNの肝癌への進展に深く関与していることが明らかにされたので、この目的で乏血性境界病変内に発生する微小な多血性巣(明らかな肝癌)の早期診断法を検討した。その結果、multi-detector row CTによるdynamic CTとdynamic MRIがこの目的で有用であることが示された。 ","subitem_description_type":"Abstract"},{"subitem_description":"Heptocellular carcinoma (HCC) often shows multi-step hepatocarcinogenesis from dysplastic nodule (DN) to overt hypervascular HCC. Therefore, it has been considered that administration of antiangiogenic factors during early stage of hepatocarcinogenesis might prevent or delay the development of HCC. For this purpose, basic and clinical studies were carried out. To investigate the morphological change of intratumoral microvessels after administration of thalidomide (antiangiogenic agent) in occult hepatic metastases experimentally induced in rats were analyzed by fluorescent vital microscopy and immunohistochemistry. Thalidomide exerted antiangiogenic effect on the occult hepatic metastases, however, the different vascular components in the tumor vasculature demonstrated various responses to antiangiogenic therapy. The vascular changes during hepatocarcinogenesis were examined with respect to vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and Flk-1), hypoxia inducible factor-1 (HIF-1), and CD34 in DNs and HCCs. The capillarized areas with increased numbers of unpaired arteries in DNs were considered to represent an early malignant transformation. Increased expression of Flk-1 and HIF-1 associated with VEGF was involved in sinusoidal capillarization and the increased numbers of unpaired arteries in these areas. To evaluate the effectiveness of gelatine hydrogel as a carrier of antiangiogenic factor for transcatheter arterial embolization therapy, bFGF (strong. angiogenic factor) contained gelatine hydrogel was directly injected into the rat liver. However, no definite effect was confirmed, and further technical improvement is necessary for this purpose. The early detection of hypervascular foci in hypovascular DNs by imaging is important to know the time of antiangiogenic therapy, and dynamic CT and/or MRI were considered to be effective in clinical practice.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18591332, 研究期間(年度):2006-2007","subitem_description_type":"Other"},{"subitem_description":"出典：「血管新生阻害剤の肝癌多段階発癌への影響のインビボ解析: 画像診断と塞栓療法への応用」研究成果報告書　課題番号18591332\n  (KAKEN：科学研究費助成事業データベース（国立情報学研究所）)\n　　　本文データは著者版報告書より作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00049402","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学 医学系研究科"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=10019961"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=10019961","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591332/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591332/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18591332/185913322007kenkyu_seika_hokoku_gaiyo/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18591332/185913322007kenkyu_seika_hokoku_gaiyo/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-21"}],"displaytype":"detail","filename":"ME-PR-MATSUI-O-kaken 2008-18p.pdf","filesize":[{"value":"752.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-MATSUI-O-kaken 2008-18p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43055/files/ME-PR-MATSUI-O-kaken 2008-18p.pdf"},"version_id":"86a2086f-0d11-4194-aeef-e9af5aca53e2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"血管新生阻害剤の肝癌多段階発癌への影響のインビボ解析: 画像診断と塞栓療法への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"血管新生阻害剤の肝癌多段階発癌への影響のインビボ解析: 画像診断と塞栓療法への応用"},{"subitem_title":"In vivo analysis of the effect of antiangiogenic drug on hepatocarcinogenesis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2826"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-21"},"publish_date":"2017-12-21","publish_status":"0","recid":"43055","relation_version_is_last":true,"title":["血管新生阻害剤の肝癌多段階発癌への影響のインビボ解析: 画像診断と塞栓療法への応用"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:24:39.675806+00:00"}