{"created":"2023-07-27T06:50:19.454947+00:00","id":43060,"links":{},"metadata":{"_buckets":{"deposit":"c2f954bd-b7ca-41b7-9bda-ff025dcc8d12"},"_deposit":{"created_by":18,"id":"43060","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43060"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043060","sets":["2812:2813:2821"]},"author_link":["69270","69271"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2010-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"マウスES細胞は多分化能を維持したまま自己複製する幹細胞株である。本研究では、Eed(エピジェネティクス制御因子)、Baf53a(クロマチンリモデリング因子)、およびLRH-1(細胞周期制御因子)の機能解析や、転写因子ネットワーク(Oct3/4、Dax1、Esrrbの相関関係やGliなど)の解析を行った。これらの因子に着目した分子生物学的解析を通して、ES細胞が自己複製する分子メカニズムの一端を明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"Mouse embryonic stem (ES) cells have two major characteristics: self-renewal capacity and pluripotency. Here, we focused on Eed (epigenetic controlling factor), Baf53a (chromatin remodeler), LRH-1 (cell cycle regulator), and transcription factor network (relationship among Oct3/4, Dax1 and Esrrb; and Gli). From the investigations of these factors, we revealed molecular mechanisms of self-renewal capacity of ES cells.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22370050, 研究期間(年度)2010-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「胚性幹細胞における自己複製機構の解析」課題番号22370050\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22370050/22370050seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00049407","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50134622"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50134622","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22370050/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22370050/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22370050/22370050seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22370050/22370050seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-21"}],"displaytype":"detail","filename":"ME-PR-YOKOTA-T-kaken 2013-6p.pdf","filesize":[{"value":"594.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-YOKOTA-T-kaken 2013-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43060/files/ME-PR-YOKOTA-T-kaken 2013-6p.pdf"},"version_id":"b12182d5-e6ed-4242-97a3-fa9751a49415"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胚性幹細胞における自己複製機構の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胚性幹細胞における自己複製機構の解析"},{"subitem_title":"Analysis of self-renewal mechanisms of embryonic stem cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-21"},"publish_date":"2017-12-21","publish_status":"0","recid":"43060","relation_version_is_last":true,"title":["胚性幹細胞における自己複製機構の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:42:48.567831+00:00"}