{"created":"2023-07-27T06:50:21.023144+00:00","id":43095,"links":{},"metadata":{"_buckets":{"deposit":"3104cfb8-95b9-433a-b956-06f53e339042"},"_deposit":{"created_by":18,"id":"43095","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43095"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043095","sets":["2812:2813:2823"]},"author_link":["86826","225"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-04-16","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヒト肝臓での発現がインスリン抵抗性および高血糖と関連する機能性ヘパトカインとしてセレノプロテインP(selenoprotein P ; SeP)を同定した。SePは主に肝臓で産生される分子量約50キロダルトンの分泌タンパクで、必須微量元素であるセレンの輸送タンパク、およびグルタチオンの酸化を介した抗酸化タンパクとして機能する。in vitroおよびin vivoの検討から、SePは、少なくとも一部にAMPキナーゼの活性抑制を介して全身のインスリン抵抗性を引き起こし、糖代謝を障害することがわかった。","subitem_description_type":"Abstract"},{"subitem_description":"We identified a gene encoding selenoprotein P (SeP), the hepatic expression levels of which were positively correlated with insulin resistance and hyperglycemia in patients with type 2 diabetes. SeP caused insulin resistance, at least partly, by inactivating AMPK both in vitro and in vivo.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「インスリン抵抗性と血管合併症を形成する肝臓由来新規ホルモンの機能解析」課題番号20591054\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591054/20591054seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00049442","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00324111"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00324111","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591054/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591054/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591054/20591054seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20591054/20591054seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-22"}],"displaytype":"detail","filename":"ME-PR-TAKAMURA-T-kaken-2011-6p.pdf","filesize":[{"value":"256.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TAKAMURA-T-kaken-2011-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43095/files/ME-PR-TAKAMURA-T-kaken-2011-6p.pdf"},"version_id":"98ac05c8-8aaa-419d-9d2d-0df9ee9494d9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"インスリン抵抗性と血管合併症を形成する肝臓由来新規ホルモンの機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"インスリン抵抗性と血管合併症を形成する肝臓由来新規ホルモンの機能解析"},{"subitem_title":"Identification of a novel hepatokine that causes insulin resistance and diabetic vascular complications","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-22"},"publish_date":"2017-12-22","publish_status":"0","recid":"43095","relation_version_is_last":true,"title":["インスリン抵抗性と血管合併症を形成する肝臓由来新規ホルモンの機能解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:18:25.502478+00:00"}