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Unexpected role of the IMD pathway in Drosophila gut defense against Staphylococcus aureus
https://doi.org/10.24517/00049486
https://doi.org/10.24517/00049486019378a1-aeeb-46b8-8c23-8b530129634a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PH-PR-KURAISHI-T-395.pdf (603.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2017-12-18 | |||||||
| タイトル | ||||||||
| タイトル | Unexpected role of the IMD pathway in Drosophila gut defense against Staphylococcus aureus | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| ID登録 | ||||||||
| ID登録 | 10.24517/00049486 | |||||||
| ID登録タイプ | JaLC | |||||||
| 著者 |
Hori, Aki
× Hori, Aki× Kurata, Shoichiro× Kuraishi, Takayuki |
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| 著者別表示 |
倉石, 貴透
× 倉石, 貴透
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| 提供者所属 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | 金沢大学医薬保健研究域薬学系 | |||||||
| 書誌情報 |
Biochemical and Biophysical Research Communications 巻 495, 号 1, p. 395-400, 発行日 2018-01-01 |
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| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0006-291X | |||||||
| NCID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00564395 | |||||||
| DOI | ||||||||
| 関連タイプ | isVersionOf | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1016/j.bbrc.2017.11.004 | |||||||
| 出版者 | ||||||||
| 出版者 | Elsevier B.V. | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | In this study, fruit fly of the genus Drosophila is utilized as a suitable model animal to investigate the molecular mechanisms of innate immunity. To combat orally transmitted pathogenic Gram-negative bacteria, the Drosophila gut is armed with the peritrophic matrix, which is a physical barrier composed of chitin and glycoproteins: the Duox system that produces reactive oxygen species (ROS), which in turn sterilize infected microbes, and the IMD pathway that regulates the expression of antimicrobial peptides (AMPs), which in turn control ROS-resistant pathogens. However, little is known about the defense mechanisms against Gram-positive bacteria in the fly gut. Here, we show that the peritrophic matrix protects Drosophila against Gram-positive bacteria S. aureus. We also define the few roles of ROS in response to the infection and show that the IMD pathway is required for the clearance of ingested microbes, possibly independently from AMP expression. These findings provide a new aspect of the gut defense system of Drosophila, and helps to elucidate the processes of gut-microbe symbiosis and pathogenesis. © 2017 The Authors. | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Embargo Period 12 months | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright © Elsevier B.V. | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 関連URI | ||||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | http://www.elsevier.com/locate/issn/0006291X | |||||||
| 関連名称 | http://www.elsevier.com/locate/issn/0006291X | |||||||
