{"created":"2023-07-27T06:50:24.296319+00:00","id":43168,"links":{},"metadata":{"_buckets":{"deposit":"17560f77-adda-4458-977c-3edad78fd6ff"},"_deposit":{"created_by":18,"id":"43168","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43168"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043168","sets":["1761:1762:1763"]},"author_link":["69431","69418","69433","69419","69425","73327","73334","73330","69423","69430","69424","69427","73329","69426","69432","69421","69422","73331","69429","73328","73333","69420","73332","69428"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"320","bibliographicPageStart":"317","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"Journal of Medical Investigation"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"竹内, 伸司"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"村山, 敏典"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"吉村, 健一"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"川上, 貴裕"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"髙原, 志津子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今井, 康人"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"栗林, 義和"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"長瀬, 克彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"矢野, 聖二"}],"nameIdentifiers":[{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The rearranged during transfection (RET) fusion gene was discovered as a driver on-cogene in 1-2% of non-small cell lung cancers (NSCLCs). Alectinib is an approved anaplastic lymphoma kinase (ALK) inhibitor that may also be effective for RET fusion-positive NSCLC. Methods/Design: RET fusion-positive NSCLC patients treated with at least one regimen of chemotherapy are being recruited. In step 1, alectinib (600 or 450 mg, twice daily) will be administered following a 3+3 design. The primary endpoint is safety. In step 2, alectinib will be administered at the recommended dose (RD) defined by step 1. The primary endpoint is the response rate of RET inhibitor treatment-naïve patients. Conclusion: This is the first study to investigate the safety and preliminary efficacy of alectinib in RET fusion-positive NSCLC patients. If successful, alectinib treatment may lead to substantial and important changes in the management of NSCLC with RET fusion genes. © 2017, University of Tokushima. All rights reserved.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学附属病院がんセンター  ","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00049515","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The University of Tokushima Faculty of Medicine"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2152/jmi.64.317","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.tokushima-u.ac.jp/med/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.tokushima-u.ac.jp/med/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.jstage.jst.go.jp/browse/jmi/-char/en"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/browse/jmi/-char/en","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © The University of Tokushima Faculty of Medicine | 許可を得て登録"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11166929","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1343-1420","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takeuchi, Shinji"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Murayama, Toshinori"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yoshimura, Kenichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kawakami, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahara, Shizuko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Imai, Yasuhito"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kuribayashi, Yoshikazu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Nagase, Katsuhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Goto, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishio, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegawa, Yoshinori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Satouchi, Miyako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kiura, Katsuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Seto, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yano, Seiji"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-11"}],"displaytype":"detail","filename":"HO-PR-TAKEUCHI-S-317.pdf","filesize":[{"value":"184.0 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"HO-PR-TAKEUCHI-S-317.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43168/files/HO-PR-TAKEUCHI-S-317.pdf"},"version_id":"c957ea83-5eff-4f6f-af96-fb941ee00a11"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Phase I/II study of alectinib in lung cancer with RET fusion gene: Study protocol","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Phase I/II study of alectinib in lung cancer with RET fusion gene: Study protocol"}]},"item_type_id":"4","owner":"18","path":["1763"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-22"},"publish_date":"2017-12-22","publish_status":"0","recid":"43168","relation_version_is_last":true,"title":["Phase I/II study of alectinib in lung cancer with RET fusion gene: Study protocol"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T17:40:58.881523+00:00"}