| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-12-28 |
| タイトル |
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|
タイトル |
Classification and visualization of physical and chemical properties of falsified medicines with handheld Raman spectroscopy and X-Ray computed tomography |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
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|
ID登録 |
10.24517/00049627 |
|
ID登録タイプ |
JaLC |
| 著者 |
Kakio, Tomoko
Yoshida, Naoko
Macha, Susan
Moriguchi, Kazunobu
Hiroshima, Takashi
Ikeda, Yukihiro
Tsuboi, Hirohito
Kimura, Kazuko
|
| 著者別表示 |
吉田, 直子
坪井, 宏仁
木村, 和子
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| 提供者所属 |
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内容記述タイプ |
Other |
|
内容記述 |
金沢大学医薬保健研究域薬学系 |
| 書誌情報 |
American Journal of Tropical Medicine and Hygiene
巻 97,
号 3,
p. 684-689,
発行日 2017-09-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0002-9637 |
| NCID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00521439 |
| DOI |
|
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.4269/ajtmh.16-0971 |
| 出版者 |
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出版者 |
American Society of Tropical Medicine and Hygiene |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Analytical methods for the detection of substandard and falsified medical products (SFs) are important for public health and patient safety. Research to understand how the physical and chemical properties of SFs can be most effectively applied to distinguish the SFs from authentic products has not yet been investigated enough. Here, we investigated the usefulness of two analytical methods, handheld Raman spectroscopy (handheld Raman) and X-ray computed tomography (X-ray CT), for detecting SFs among oral solid antihypertensive pharmaceutical products containing candesartan cilexetil as an active pharmaceutical ingredient (API). X-ray CT visualized at least two different types of falsified tablets, one containing many cracks and voids and the other containing aggregates with high electron density, suchasfrom the presence of theheavy elements. Generic products that purported to contain equivalent amounts of A PIto the authentic products were discriminated from the authentic products by the handheld Raman and the different physical structure on X-ray CT. Approachto investigate both the chemical and physical properties with handheld Raman and X-ray CT, respectively, promise the accurate discrimination of the SFs, even if their visual appearance is similar with authentic products. We present a decision tree for investigating the authenticity of samples purporting to be authentic commercial tablets. Our results indicate that the combination approach of visual observation, handheld Raman and X-ray CT is a powerful strategy for nondestructive discrimination of suspect samples. © Copyright 2017 by The American Society of Tropical Medicine and Hygiene. |
| 内容記述 |
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内容記述タイプ |
Other |
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内容記述 |
Embargo Period 12 months |
| 権利 |
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|
権利情報 |
Copyright © American Society of Tropical Medicine and Hygiene |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
PH-PR-YOSHIDA-N-684.pdf (4.2 MB)
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