| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-12-28 |
| タイトル |
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|
タイトル |
Serum microRNA profiles in patients with chronic hepatitis B, chronic hepatitis C, primary biliary cirrhosis, autoimmune hepatitis, nonalcoholic steatohepatitis, or drug-induced liver injury |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00049639 |
|
ID登録タイプ |
JaLC |
| 著者 |
Yamaura, Yu
Tatsumi, Naoyuki
Takagi, Shingo
Tokumitsu, Shinsaku
Fukami, Tatsuki
Tajiri, Kazuto
Minemura, Masami
Yokoi, Tsuyoshi
Nakajima, Miki
|
| 著者別表示 |
深見, 達基
横井, 毅
中嶋, 美紀
|
| 提供者所属 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
金沢大学ナノ生命科学研究所 / 金沢大学医薬保健研究域薬学系 |
| 書誌情報 |
Clinical Biochemistry
巻 50,
号 18,
p. 1034-1039,
発行日 2017-12-01
|
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0009-9120 |
| NCID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00607603 |
| DOI |
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|
関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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|
関連識別子 |
10.1016/j.clinbiochem.2017.08.010 |
| 出版者 |
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出版者 |
Elsevier Inc. |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Purpose: Some blood biomarkers or histological examination by liver biopsy are used for the diagnosis of liver diseases in clinics. However, conventional blood biomarkers show poor specificity and sensitivity, and liver biopsy is highly invasiveness. Therefore, to overcome such disadvantages, specific/sensitive and noninvasive options are desirable. In recent years, circulating microRNAs (miRNAs) have been acknowledged for their potential as disease markers. Actually, several miRNAs have been reported to be biomarker candidates of liver diseases. However, these earlier studies were performed for one disease. Therefore, the specificity as biomarkers was not guaranteed, because they didn't study for the other types of liver injury. In this study, we examined if circulating miRNA could distinguish different types of liver diseases. Methods: Serum miRNA profiles in 28 patients with chronic hepatitis B, chronic hepatitis C, primary biliary cirrhosis, autoimmune hepatitis, nonalcoholic steatohepatitis or drug-induced liver injury as well as 4 control subjects were determined by TaqMan MicroRNA Array analysis. Principal component analysis (PCA) of selected miRNAs was performed. Results: We identified 37 miRNAs whose levels were significantly different between any of the groups. Although individual miRNAs could not distinguish different types of liver diseases, probably because of similar liver pathology, their profiling by PCA could classify different liver disease groups. Conclusions: The profiling of the selected miRNAs can be useful to distinguish different types of liver diseases. © 2017 The Canadian Society of Clinical Chemists. |
| 内容記述 |
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内容記述タイプ |
Other |
|
内容記述 |
Embargo Period 12 months |
| 権利 |
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|
権利情報 |
Copyright © Elsevier Inc. |
| 著者版フラグ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連URI |
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|
識別子タイプ |
URI |
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|
関連識別子 |
http://www.elsevier.com/locate/issn/00099120 |
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|
関連名称 |
http://www.elsevier.com/locate/issn/00099120 |
PH-PR-NAKAJIMA-M-1034.pdf (1.9 MB)
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