@article{oai:kanazawa-u.repo.nii.ac.jp:00043329,
 author = {小川, 数馬 and 北村, 陽二 and 小阪, 孝史 and 柴, 和弘 and 小谷, 明 and Ogawa, Kazuma and Ishizaki, Atsushi and Takai, Kenichiro and Kitamura, Yoji and Makino, Akira and Kozaka, Takashi and Kiyono, Yasushi and Shiba, Kazuhiro and Odani, Akira},
 issue = {1},
 journal = {Scientific Reports},
 month = {Dec},
 note = {67Ga-DOTA-(L-Asp)11 and 67Ga-DOTA-(L-Asp)14, which have been developed as bone imaging agents, showed a high accumulation in bone and a rapid blood clearance in mice. However, peptides composed of D-amino acids are more stable in vivo than those composed of their L-equivalents. In this study, 67Ga-DOTA-(D-Asp)n (n = 2, 5, 8, 11, or 14) were synthesized using the Fmoc-based solid-phase methodology and evaluated. In hydroxyapatite binding assay, binding of 67Ga-DOTA-(D-Asp)n tended to increase with increasing length of the amino acid chain. 67Ga-DOTA-(D-Asp)11 and 67Ga-DOTA-(D-Asp)14 caused a high accumulation of radioactivity in the bones of the mice. However, the results for 67Ga-DOTA-(D-Asp)n and 67Ga-DOTA-(L-Asp)n were comparable. In urine analyses, the proportion of intact complex after injection of 67Ga-DOTA-(D-Asp)14 was significantly higher than that of 67Ga-DOTA-(L-Asp)14. Although 67Ga-DOTA-(D-Asp)14 was more stable than 67Ga-DOTA-(L-Asp)14, the properties of 67Ga-DOTA-(D-Asp)n and 67Ga-DOTA-(L-Asp)n as bone imaging agents may be comparable. © 2017 The Author(s)., 金沢大学新学術創成研究機構},
 title = {Evaluation of Ga-DOTA-(D-Asp)n as bone imaging agents: D-aspartic acid peptides as carriers to bone},
 volume = {7},
 year = {2017}
}