{"created":"2023-07-27T06:50:30.813715+00:00","id":43376,"links":{},"metadata":{"_buckets":{"deposit":"97e8aa4d-9086-4f50-9d31-ab605286b115"},"_deposit":{"created_by":18,"id":"43376","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43376"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043376","sets":["1132:1133:1134"]},"author_link":["73409","70168","68650","70167","70169","73408","70172","70170","70171"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"71","bibliographicPageStart":"62","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"Topics in Catalysis"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小泉, 順二"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"稲津, 明広"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"梶波, 康二"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"馬渕, 宏"}],"nameIdentifiers":[{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A study was conducted to determine the clinical efficacy and tolerability of simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase in seven patients with heterozygous familial hypercholesterolemia (FH) (defined as primary hypercholesterolemia with tendon xanthoma or primary hypercholesterolemia without tendon xanthomas and at least one first-degree relative with familial hypercholesterolemia). These patients were administrated 10 mg/d of simvastatin for up to 4 years. Simvastatin significantly reduced levels of both total cholesterol and low-density lipoprotein cholesterol during treatment; respective reduction rates were 28% and 34% after 1 month and 32% and 40% after 4 years. Serum high-density lipoprotein cholesterol levels slightly and insignificantly increased. Serum triglyseride levels fell significantly by 24% at month 6. After this study, all xanthomas had reduced in size. No adverse events related to simvastatin were observed. We conclude that long-term simvastatin therapy is clinically useful and well tolerated in patients with FH. Copyright © 1985 Published by Elsevier Inc.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域保健学系 ","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00049722","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/S0011-393X(96)80031-2","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.elsevier.com/locate/issn/0011393X"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.elsevier.com/locate/issn/0011393X","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 1985 Published by Elsevier Inc."}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00622254","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0011-393X","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kitatani, Masako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koizumi, Junji"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Inazu, Akihiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kajinami, Kouji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mabuchi, Hiroshi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-11"}],"displaytype":"detail","filename":"ME-PR-INAZU-A-62.pdf","filesize":[{"value":"503.4 kB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"ME-PR-INAZU-A-62","url":"https://kanazawa-u.repo.nii.ac.jp/record/43376/files/ME-PR-INAZU-A-62.pdf"},"version_id":"1106f4e8-67d6-4c89-859c-ef998b7742a4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A 4-year trial of simvastatin in the treatment of patients with heterozygous familial hypercholesterolemia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A 4-year trial of simvastatin in the treatment of patients with heterozygous familial hypercholesterolemia"}]},"item_type_id":"4","owner":"18","path":["1134"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-01-11"},"publish_date":"2018-01-11","publish_status":"0","recid":"43376","relation_version_is_last":true,"title":["A 4-year trial of simvastatin in the treatment of patients with heterozygous familial hypercholesterolemia"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T17:40:39.877107+00:00"}