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Urinary trypsin inhibitor: Production in the liver and reabsorption in the kidney of the rat
https://doi.org/10.24517/00049829
https://doi.org/10.24517/0004982945c59dce-fa7b-4fd1-a68b-ba3171c75f44
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ME-PR-ISEKI-S-227.pdf (17.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2019-11-14 | |||||||||
| タイトル | ||||||||||
| タイトル | Urinary trypsin inhibitor: Production in the liver and reabsorption in the kidney of the rat | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.24517/00049829 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| 著者 |
Wakayama, Tomohiko
× Wakayama, Tomohiko× Mizushima, Seiichi× Hirose, Jiro× Iseki, Shoichi |
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| 著者別表示 |
若山, 友彦
× 若山, 友彦
× 井関, 尚一
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| 提供者所属 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 金沢大学医薬保健研究域医学系 | |||||||||
| 書誌情報 |
Acta Histochemica et Cytochemica 巻 29, 号 3, p. 227-236, 発行日 1996 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0044-5991 | |||||||||
| NCID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00508022 | |||||||||
| 出版者 | ||||||||||
| 出版者 | Acta histochemica et cytochemica = 日本組織細胞化学会 | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Human urinary trypsin inhibitor (UTI) is the functional domain of serum inter-a-trypsin inhibitor. Rat urine also contains UTI-like immunoreactivity. To clarify the source of rat UTI, we performed a combination of reverse transcription-polymerase chain reaction (RT-PCR), in situ hybridization and immunohistochemistry. The expression of UTI mRNA was detected by RT-PCR only in the liver and not in any other rat organs, including the kidney. In situ hybridization revealed that UTI transcripts are located exclusively in the hepatocytes and not in the nonparenchymal cells of the liver. On light microscopic immunohistochemistry, not only the hepatocytes but also the Kupffer cells of liver and the proximal tubules of kidney were immunostained with anti-UTI antibody. Immunoelectron microscopy further demonstrated that hepatocyte UTI-immunoreactivity is localized primarily on the cell surface facing the sinusoidal capillary and is also found in the Golgi apparatus. In contrast, the reactivity of Kupffer cell and proximal tubular epithelial cell was found primarily in the lysosomes. These results indicated that the liver is the only site for production of rat UTI, and that the kidney does not produce rat UTI but reabsorbs it from the primary urine. | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 出版者許可を得て登録 20191114 | |||||||||
| 権利 | ||||||||||
| 権利情報 | Copyright © Acta histochemica et cytochemica 日本組織細胞化学会 | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 関連URI | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | https://www.jstage.jst.go.jp/browse/ahc/-char/en | |||||||||
| 関連名称 | https://www.jstage.jst.go.jp/browse/ahc/-char/en | |||||||||
| 関連URI | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | http://jshc.nacos.com/ | |||||||||
| 関連名称 | http://jshc.nacos.com/ | |||||||||
