@article{oai:kanazawa-u.repo.nii.ac.jp:00043490,
 author = {太田, 哲生 and 山本, 美由紀 and 井関, 尚一 and 宮下, 知治 and 萱原, 正都 and 永川, 宅和 and 宮崎, 逸夫 and 西川, 克三 and Ohta, Tetsuo and Yamamoto, Miyuki and Numata, Masayuki and Iseki, Shoichi and Tsukioka, Yuhji and Miyashita, Tomoharu and Kayahara, Masato and Nagakawa, Takukazu and Miyazaki, Itsuo and Nishikawa, Katsuzo and Yoshitake, Yoshino},
 issue = {4},
 journal = {British Journal of Cancer},
 month = {Oct},
 note = {We examined the expression of basic fibroblast growth factor (FGF) and FGF receptor by immunohistochemistry in 32 human pancreatic ductal adenocarcinomas. Mild to marked basic FGF immunoreactivity was noted in 19 (59.4%) of the 32 tumours examined, and 30 (93.3%) of the tumours exhibited a cytoplasmic staining pattern against FGF receptor. The tumours were divided into two groups according to the proportion of positively stained tumour cells: A low expression group (positive cells ≪ 25%) and a high expression group (positive cells > or = 25%). No statistically significant difference in tumour size, differentiation, metastases or stage was found between the low and high basic FGF expression groups. However, a significant correlation was found between FGF receptor expression level and the presence of retroperitoneal invasion, lymph node metastasis, and tumour stage. In addition, low FGF receptor expression was significantly associated with a longer post-operative survival as compared with high FGF receptor expression, whereas there was no significant difference in post-operative survival between the low and high basic FGF expression groups. Increased expression of FGF receptor is correlated with the extent of malignancy and post-operative survival in human pancreatic ductal adenocarcinomas. Thus, overexpression of FGF receptor may prove to be a more useful prognostic marker than basic FGF expression level in pancreatic cancer patients. © 1995 Stockton Press. All rights reserved., Embargo Period 12 months, 金沢大学医薬保健研究域医学系},
 pages = {824--831},
 title = {Expression of basic fibroblast growth factor and its receptor in human pancreatic carcinomas},
 volume = {72},
 year = {1995}
}