@article{oai:kanazawa-u.repo.nii.ac.jp:00043497,
 author = {田島, 秀浩 and 高村, 博之 and 北川, 裕久 and 中村, 信一 and 岡本, 浩一 and 木下, 淳 and 牧野, 勇 and 中村, 慶史 and 林, 泰寛 and 尾山, 勝信 and 井口, 雅史 and 中川原, 寿俊 and 宮下, 知治 and 二宮, 致 and 若山, 友彦 and 藤村, 隆 and 若山, 友彦 and 井関, 尚一 and 池田, 博子 and 太田, 哲生 and Tajima, Hidehiro and Takamura, Hiroyuki and Kitagawa, Hirohisa and Nakayama, Akira and Shoji, Masatoshi and Watanabe, Toshifumi and Tsukada, Tomoya and Nakanuma, Shinichi and Okamoto, Koichi and Sakai, Seisho and Kinoshita, Jun and Makino, Isamu and Nakamura, Keishi and Hayashi, Hironori and Oyama, Katsunobu and Inokuchi, Masafumi and Nakagawara, Hisatoshi and Miyashita, Tomoharu and Ninomiya, Itasu and Fushida, Sachio and Fujimura, Takashi and Wakayama, Tomohiko and Iseki, Shoichi and Ikeda, Hiroko and Ohta, Tetsuo},
 issue = {4},
 journal = {Oncology Letters},
 month = {Apr},
 note = {A 33-year-old female was diagnosed with a solid pseudopapillary tumor (SPT) of the pancreas and multiple liver metastases at the Department of Gastroenterological Surgery, Ishikawa Prefectural Central Hospital (Kanazawa, Japan). Distal pancreatectomy and postoperative systemic chemotherapy with gemcitabine (GEM) and S-1, an oral fluoropyrimidine derivative, was administered, however, liver metastases became enlarged and local recurrence occurred. Therefore, the patient was referred to the Department of Gastroenterologic Surgery at the Graduate School of Medicine (Kanazawa, Japan) for hepatic arterial infusion (HAI) chemotherapy. Oral S-1 (80 mg/m2) was administered as well as HAI chemotherapy with GEM (1,000 mg/standard liver volume). Following 18 cycles, tumor sizes were reduced and 18-fluorodeoxyglucose positron emission tomography (18FDG-PET) examination revealed obvious reduction of tumor FDG uptake. Transarterial tumor embolization (TAE) was performed for the previously unresectable right subphrenic liver tumor, and the other tumors were surgically resected. The resected tumors were diagnosed as liver metastases and a local recurrence of SPT in the postoperative pathological examination, which revealed that the resected tumors were composed of sheets of bland cells, which were positive for CD10, CD56, vimentin, neuron-specific enolase and α-antitrypsin. The postoperative course was uneventful, and the patient is currently under observation at an outpatient clinic; postoperative adjuvant chemotherapy with oral S-1 has continued, and additional TAE is planned. In the future, if the middle segment of the liver becomes enlarged, surgery for the residual right lobe tumor may be possible. This case demonstrates one method of SPT treatment: Preoperative HAI chemotherapy with GEM, plus oral S-1 and TAE. If complete resection can be achieved, the majority of patients with SPT have a favorable prognosis. In patients with unresectable metastases from SPT, it is crucial to conduct systematic multimodal treatment to maximize treatment success. © 2015, Spandidos Publications. All Rights Reserved., Embargo Period 6 months, 金沢大学医薬保健研究域医学系},
 pages = {1733--1738},
 title = {Multiple liver metastases of pancreatic solid pseudopapillary tumor treated with resection following chemotherapy and transcatheter arterial embolization: A case report},
 volume = {9},
 year = {2015}
}