{"created":"2023-07-27T06:50:35.316296+00:00","id":43552,"links":{},"metadata":{"_buckets":{"deposit":"06baa10d-2fed-4cc6-8030-6eeaf183d2b4"},"_deposit":{"created_by":18,"id":"43552","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43552"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043552","sets":["2812:2813:2822"]},"author_link":["71327","71328"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kitaura, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"71328","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00143868","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00143868"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ドーピング規制薬物である喘息治療薬のβ^2アドレナリン受容体作動薬の影響を解明するために、クレンブテロールの鏡像異性体の(+)-S-体と(-)-R-体を用いて,遺伝子及び蛋白質レベルで検討を行った。その結果,心臓と骨格筋の筋肥大を誘発するが受容体の少ない速筋への作用が大きく,核内転写調節因子の発現が筋によって異なること及び蛋白質の結果がmRNAの結果と同期しないことや(+)-S-体が骨の成長を強く抑制することを解明した。","subitem_description_type":"Abstract"},{"subitem_description":"Clenbuterol(CLE) is one of the beta-2 adrenergic receptor agonists with powerful muscle anabolic and lipolytic effects and is prohibited to use as doping drug for athletes. It is manufactured as a 1 : 1 racemic mixture of two enantiomers,(-)-R and(+)-S isomers.\nThe both enantiomers induced the increased cardiac and skeletal muscles mass.\nParticularly, fast-twitch extensor digitorum longus muscle having less beta-2 adrenergic receptor was affected more strongly. The expression of MyoD mRNAs by enantiomers was different between fast and slow-twitch muscles, but the results in proteins were not synchronized with the changes of mRNAs. Furthermore, the(+)-S isomer strongly inhibited the femurs and tibiae bones.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21500628, 研究期間(年度):2009-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ドーピング規制薬物(アドレナリン受容体作動薬)の影響における分子機構の解明」課題番号21500628\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21500628/21500628seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00049894","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学保健管理センター"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=00143868"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=00143868","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21500628/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21500628/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21500628/21500628seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21500628/21500628seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"北浦, 孝"}],"nameIdentifiers":[{"nameIdentifier":"71327","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00143868","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00143868"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-29"}],"displaytype":"detail","filename":"HE-PR-KITAURA-T-kaken 2012-4p.pdf","filesize":[{"value":"363.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"HE-PR-KITAURA-T-kaken 2012-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43552/files/HE-PR-KITAURA-T-kaken 2012-4p.pdf"},"version_id":"0b636955-11db-4613-b20e-f42100391e70"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ドーピング規制薬物(アドレナリン受容体作動薬)の影響における分子機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ドーピング規制薬物(アドレナリン受容体作動薬)の影響における分子機構の解明"},{"subitem_title":"Research of the molecular mechanism in effects of doping drugs(adrenergic agonists)","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-01-29"},"publish_date":"2018-01-29","publish_status":"0","recid":"43552","relation_version_is_last":true,"title":["ドーピング規制薬物(アドレナリン受容体作動薬)の影響における分子機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:57:53.207710+00:00"}