{"created":"2023-07-27T06:50:42.295085+00:00","id":43722,"links":{},"metadata":{"_buckets":{"deposit":"b60e96ed-df28-453b-863d-f8e413a6947c"},"_deposit":{"created_by":18,"id":"43722","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43722"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043722","sets":["2812:2813:2820"]},"author_link":["27528","71919"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011-04-01 – 2014-03-31","bibliographic_titles":[{"bibliographic_title":"平成25(2013)年度 科学研究費補助金 若手研究(A) 研究成果報告書"},{"bibliographic_title":"2013 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hinoi, Eiichi"}],"nameIdentifiers":[{"nameIdentifier":"27528","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70360865","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70360865"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アミノ酸は、細胞機能調節因子（シグナル伝達分子）として能動的に働くことが近年注目されている。本研究では、システムA型中性アミノ酸トランスポーターであるSlc38a1の骨関連細胞（骨芽細胞と破骨細胞）特異的遺伝子欠損マウス(KOマウス）を作製し、骨表現型解析を行った。その結果、どちらの細胞特異的KOマウスにおいても、野生型マウスと比較して、骨量、骨形成・骨吸収パラメーターに著明な変化は認められなかった。また、骨芽細胞特異的KOマウスを用いて卵巣摘出による閉経後骨粗鬆症モデルを作成した。その結果、野生型マウスおよび骨芽細胞特異的KOマウスのどちらも同程度の骨量低下が認められた。","subitem_description_type":"Abstract"},{"subitem_description":"Although amino acid transporters are indispensable for a variety of cellular events in eukaryotic cells, little attention has been paid to their functional role in bone modeling and remodeling so far. Here, we have attempted to demonstrate the possible involvement of a system A amino acid transporter Slc38a1 in the regulation of osteoblastogenesis and osteoclastogenesis in vivo. To that end, cell-specific (osteoblast and osteoclast) knockout mice were generated. In vertebrae of those knockout mice, no marked change was seen in bone volume over tissue volume, osteoblastic parameter and osteoclastic parameter compared with wild-type (WT) mice by bone histomorphometric analyses. Moreover, ovariectomy resulted in a marked reduction of vertebrae bone volume in both WT mice and osteoblast-specific Slc38a1 knockout mice.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23689004, 研究期間(年度):2011-04-01 – 2014-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「アミノ酸シグナルによる骨代謝調節機構」課題番号:23689004\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23689004/23689004seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050064","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域薬学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=70360865"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=70360865","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23689004/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23689004/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23689004/23689004seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23689004/23689004seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"檜井, 栄一"}],"nameIdentifiers":[{"nameIdentifier":"71919","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70360865","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70360865"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-08"}],"displaytype":"detail","filename":"PH-PR-HINOI-E-kaken 2014A-4p.pdf","filesize":[{"value":"185.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-HINOI-E-kaken 2014A-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43722/files/PH-PR-HINOI-E-kaken 2014A-4p.pdf"},"version_id":"c6a9e404-0d47-4a93-a03f-6f341d564546"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"アミノ酸シグナルによる骨代謝調節機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アミノ酸シグナルによる骨代謝調節機構"},{"subitem_title":"The regulation of bone metabolism by amino acid","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2820"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-08"},"publish_date":"2018-02-08","publish_status":"0","recid":"43722","relation_version_is_last":true,"title":["アミノ酸シグナルによる骨代謝調節機構"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:51:42.067549+00:00"}