{"created":"2023-07-27T06:50:42.434285+00:00","id":43725,"links":{},"metadata":{"_buckets":{"deposit":"6075e498-9df4-4441-b0a3-76042dfae94a"},"_deposit":{"created_by":18,"id":"43725","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43725"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043725","sets":["2812:2813:2823"]},"author_link":["297","71925"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2008-2010","bibliographic_titles":[{"bibliographic_title":"平成22(2010)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2010 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"咳嗽反応の末梢機序には少なくとも以下の2つ経路が存在することが明らかとなった。(1)気道表層の気管支上皮間や上皮下に存在する知覚神経終末(咳受容体)の感受性亢進(アトピー咳嗽)あるいは過剰刺激による咳嗽反応(副鼻腔気管支症候群)、(2)気管支壁深層の平滑筋層の中または周囲に存在する知覚神経終末(Aδ線維)の平滑筋収縮に対する過剰反応(咳喘息)、あるいは過剰な平滑筋収縮による過刺激(気管支喘息)。","subitem_description_type":"Abstract"},{"subitem_description":"It has been disclosed that there are at least two pathway of cough reflex : (1) increased cough receptor sensitivity (atopic cough) or hyper-stimulation to cough receptors (sinobronchial syndrome) which are present in inter- and sub epithelium of airway, (2) increased response of sensory nerve endings (Adelta-fibers) in intra- and peri-smooth muscle layer to the smooth muscle contraction (cough variant asthma) or hyper-stimulation (strong smooth muscle contraction) to the nerve endings.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:20590916, 研究期間(年度):2008-2010","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「難治性慢性咳嗽の克服に向けて: 咳嗽発生メカニズムの機序解明と治療法の開発」課題番号20590916\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590916/20590916seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域医学系","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050067","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90190066"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90190066","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590916/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590916/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590916/20590916seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20590916/20590916seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-08"}],"displaytype":"detail","filename":"ME-PR-FUJIMURA-M-kaken 2011-6p.pdf","filesize":[{"value":"273.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-FUJIMURA-M-kaken 2011-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43725/files/ME-PR-FUJIMURA-M-kaken 2011-6p.pdf"},"version_id":"c6b0d126-12c2-4856-ad9c-2b0a222fcba2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"難治性慢性咳嗽の克服に向けて: 咳嗽発生メカニズムの機序解明と治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"難治性慢性咳嗽の克服に向けて: 咳嗽発生メカニズムの機序解明と治療法の開発"},{"subitem_title":"To overcome intractable chronic cough: mechanism of cough and development of therapy","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2823"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-08"},"publish_date":"2018-02-08","publish_status":"0","recid":"43725","relation_version_is_last":true,"title":["難治性慢性咳嗽の克服に向けて: 咳嗽発生メカニズムの機序解明と治療法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:18:17.255975+00:00"}