{"created":"2023-07-27T06:50:42.614564+00:00","id":43729,"links":{},"metadata":{"_buckets":{"deposit":"9e897e3a-9ba3-4072-b3c7-bf94b5731995"},"_deposit":{"created_by":18,"id":"43729","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43729"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043729","sets":["2812:2813:2822"]},"author_link":["20157","71928"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"GluやNMDAに対する脆弱性相違に、ミトコンドリア膜電位、mPTP形成能、ミトコンドリア内Ca^<2+>濃度、およびUCP2発現量等の相違が少なくとも一部は関与する可能性が判明した。人工的NMDARチャネルにさらにUCP2発現ベクターを導入すると、NMDA曝露に伴ってミトコンドリア内遊離Ca^<2+>濃度の著明な上昇とともに、著明な細胞死が出現した。海馬神経細胞におけるNMDA毒性脆弱性の出現には、ミトコンドリア内膜に発現するUCP2発現量が関与すると推察される。","subitem_description_type":"Abstract"},{"subitem_description":"Glutamate neurotoxicity was found to at least in part involve mitochondrial membrane potential disruption, mPTP orchestration, mitochondrial free Ca^<2+> levels and UCP2 expression in rat hippocampal and cortical neurons. In HEK293 cells with acquired NMDAR channels and overexpressed UCP2, a more marked increase was seen in mitochondrial free Ca^<2+> levels, in addition to more severe cell death, after the exposure to NMDA than in cells without UCP2 overexpression. Accordingly, UCP2 could play a role as a determinant of the neurotoxicity mediated by NMDAR through a mechanism related to the modulation of mitochondrial free Ca^<2+> levels in neurons.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21659018, 研究期間(年度):2009-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ミトコンドリアと神経細胞死」課題番号21659018\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21659018/21659018seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050071","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学医薬保健研究域薬学系"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=50094454"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=50094454","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21659018/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21659018/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21659018/21659018seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21659018/21659018seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-09"}],"displaytype":"detail","filename":"PH-PR-YONEDA-Y-kaken 2012-4p.pdf","filesize":[{"value":"204.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-YONEDA-Y-kaken 2012-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43729/files/PH-PR-YONEDA-Y-kaken 2012-4p.pdf"},"version_id":"1f155577-c4e4-46a0-8994-0819dcbd7fc4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ミトコンドリアと神経細胞死","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ミトコンドリアと神経細胞死"},{"subitem_title":"Neuronal cell death mediated by mitochondria","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-09"},"publish_date":"2018-02-09","publish_status":"0","recid":"43729","relation_version_is_last":true,"title":["ミトコンドリアと神経細胞死"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:28:40.178719+00:00"}