{"created":"2023-07-27T06:50:42.929249+00:00","id":43736,"links":{},"metadata":{"_buckets":{"deposit":"5898603f-5c0c-4cbb-8ae8-06b9958fd3ca"},"_deposit":{"created_by":18,"id":"43736","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43736"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043736","sets":["2812:2813:2817"]},"author_link":["70020","71938"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2014-04-01 – 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"組織幹細胞である間葉系幹細胞（MSC)の個体レベルでの性質の多くは謎に包まれている。Runx2コンディショナル欠損マウスを独自に開発し、同マウスでの遺伝学的解析とフローサイトメトリー解析を組み合わせた解析結果から、Prx1とSca1 が共陽性なMSCが最も幹細胞性の高いMSCであり、まずSca1陰性となり、次にPrx1陰性 なOsterix陽性細胞となり、そして成熟した骨芽細胞となる、という骨形成への分化過程の詳細を明らかにした。つまり、「生体内」でのMSCの細胞生物学的な特徴（どのようなMSCが、どのような系列をたどり、どのような細胞となり、どのような機能を有するか）の一端が見えてきた。 ","subitem_description_type":"Abstract"},{"subitem_description":"The cellular origin and essential period for Runx2 function during osteoblast differentiation in intramembranous ossification remain poorly understood. Paired related homeobox 1 (Prx1) is expressed in craniofacial mesenchyme, and Runx2 deficiency in Prx1+-derived cells (Runx2prx1－/－ mice) resulted in defective intramembranous ossification. Double-positive cells for Prx1-GFP and stem cell antigen-1 (Sca1) (Prx1+Sca1+ cells) in the calvaria expressed Runx2 at lower levels and were more homogeneous and primitive as compared with Prx1+Sca1－ cells. These findings indicate that the essential period of Runx2 function on intramembranous ossification would begin at the Prx1+Sca1+ mesenchymal stem cell stage and end at the Osx+Prx1－Sca1－ osteoblast precursor stage.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:26460387, 研究期間(年度):2014-04-01 – 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「Runx2コンディショナル欠損マウスを使用した成体間葉系幹細胞の機能解析」研究成果報告書　課題番号26460387\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460387/26460387seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系 / 岡山大学医歯薬学総合研究科","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050078","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30377428"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30377428","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460387/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460387/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460387/26460387seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460387/26460387seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-11"}],"displaytype":"detail","filename":"ME-PR-TAKARADA-T-kaken 2017-4p.pdf","filesize":[{"value":"167.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ME-PR-TAKARADA-T-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43736/files/ME-PR-TAKARADA-T-kaken 2017-4p.pdf"},"version_id":"de940efa-6efc-4b21-9f79-90fee7bf1eaa"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Runx2コンディショナル欠損マウスを使用した成体間葉系幹細胞の機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Runx2コンディショナル欠損マウスを使用した成体間葉系幹細胞の機能解析"},{"subitem_title":"In vivo analysis of Mesenchymal stem cells using Runx2 conditional KO mouse","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-11"},"publish_date":"2018-06-11","publish_status":"0","recid":"43736","relation_version_is_last":true,"title":["Runx2コンディショナル欠損マウスを使用した成体間葉系幹細胞の機能解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T11:34:06.829067+00:00"}