{"created":"2023-07-27T06:50:43.194640+00:00","id":43743,"links":{},"metadata":{"_buckets":{"deposit":"4f187aab-8cb4-488d-83f6-23b33423cb70"},"_deposit":{"created_by":18,"id":"43743","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43743"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043743","sets":["2812:2813:2818"]},"author_link":["227","71948"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2013-04-01 – 2016-03-31","bibliographic_titles":[{"bibliographic_title":"平成27(2015)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2015 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"SOX17遺伝子はSOXファミリーに属する転写因子で、腫瘍形成に関与すると考えられている。また、SOX17はWntシグナル標的因子として報告されているが、大腸がん細胞ではSOX17の発現低下が報告され、がん抑制遺伝子としての可能性も示唆されている。よって、SOX17が、向腫瘍性か抗腫瘍性に作用するのかは未だ明らかとされていない。本研究では、各種マウスモデルを用いて遺伝学的解析により、腫瘍の悪性化過程におけるSOX17の役割について解析した。本研究により、SOX17は腫瘍発生初期からWntシグナル依存的に発現誘導されるが、腫瘍発生過程と粘膜下浸潤過程のどちらにも関わっていない可能性が示された。","subitem_description_type":"Abstract"},{"subitem_description":"Transcription factor SOX17 has been shown to function as “tumor promoter” and also “tumor suppressor”, and the role of SOX17 in tumorigenesis has not yet been elucidated. In this project, the roles of SOX17 in intestinal tumor development and malignant progression with submucosal invasion have been examined by mouse genetic studies. We found that SOX17 expression is induced by Wnt signaling-dependent manner in tumor cells. However, disruption of SOX17 gene did not cause any morphological change of intestinal tumors. Moreover, the number, size, and invasion status of intestinal tumors were not changed by SOX17 disruption. These results indicate that SOX17 is dispensable for intestinal tumor development and malignant progression.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25430107, 研究期間(年度):2013-04-01 – 2016-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「SOX17発現抑制と炎症反応の相互作用によるがん悪性化機構の研究」課題番号25430107\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25430107/25430107seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050085","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80362515"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80362515","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25430107/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25430107/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25430107/25430107seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25430107/25430107seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-09"}],"displaytype":"detail","filename":"CA-PR-OSHIMA-H-kaken 2016-4p.pdf","filesize":[{"value":"165.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-OSHIMA-H-kaken 2016-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43743/files/CA-PR-OSHIMA-H-kaken 2016-4p.pdf"},"version_id":"609e19c6-87a5-48f5-88c0-806e1a5f561b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"SOX17発現抑制と炎症反応の相互作用によるがん悪性化機構の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"SOX17発現抑制と炎症反応の相互作用によるがん悪性化機構の研究"},{"subitem_title":"SOX17 suppression and inflammation in malignant cancer progression","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2818"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-09"},"publish_date":"2018-02-09","publish_status":"0","recid":"43743","relation_version_is_last":true,"title":["SOX17発現抑制と炎症反応の相互作用によるがん悪性化機構の研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:57:15.264093+00:00"}