{"created":"2023-07-27T06:50:43.238716+00:00","id":43744,"links":{},"metadata":{"_buckets":{"deposit":"acc1a72b-b820-4b90-8b65-7b76ca9c98bd"},"_deposit":{"created_by":18,"id":"43744","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43744"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043744","sets":["2812:2813:2821"]},"author_link":["71949","71947"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2010-2012","bibliographic_titles":[{"bibliographic_title":"平成24(2012)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2012 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"転写因子であるSOX17は、消化管腫瘍の発生に対して「発がん促進」に作用する可能性と、「発がん抑制」に作用する可能性が指摘されており、その役割は未だ不明である。本研究では、マウスモデルを用いた遺伝学的解析により、腸管腫瘍発生におけるSOX17の役割を解析した。その結果、SOX17遺伝子を欠損させたApc^Δ716 マウスでは腸粘膜が肥厚し、腸管腫瘍数の有意な増加を認めたことから、SOX17は大腸がん発生に関して抑制的に作用すると考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"Transcription factor SOX17 has shown to function as “tumor promoter” and also “tumor suppressor”, and the role of SOX17 in tumorigenesis has not yet been elucidated. In this project, the role of SOX17 in intestinal tumorigenesis has been examined by genetic studies. Disruption of SOX17 in Apc^Δ716 mouse model resulted in thickened gastric mucosa and significant increase of colonic polyps. These results indicate that SOX17 functions as tumor suppressor in colon cancer development.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22500996, 研究期間(年度):2010-2012","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「SOX17の発現変化によるWnt活性制御が消化管腫瘍悪性化に及ぼす影響」課題番号22500996\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22500996/22500996seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050086","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=80362515"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=80362515","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500996/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500996/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22500996/22500996seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22500996/22500996seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-09"}],"displaytype":"detail","filename":"CA-PR-OSHIMA-H-kaken 2013-4p.pdf","filesize":[{"value":"399.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-OSHIMA-H-kaken 2013-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43744/files/CA-PR-OSHIMA-H-kaken 2013-4p.pdf"},"version_id":"fc51ea6c-aa9e-468f-a65a-1f144c13bfd2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"SOX17の発現変化によるWnt活性制御が消化管腫瘍悪性化に及ぼす影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"SOX17の発現変化によるWnt活性制御が消化管腫瘍悪性化に及ぼす影響"},{"subitem_title":"Regulation of Wnt activity by SOX17 in gastrointestinal tumorigenesis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-09"},"publish_date":"2018-02-09","publish_status":"0","recid":"43744","relation_version_is_last":true,"title":["SOX17の発現変化によるWnt活性制御が消化管腫瘍悪性化に及ぼす影響"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T12:42:41.685575+00:00"}