{"created":"2023-07-27T06:50:43.327098+00:00","id":43746,"links":{},"metadata":{"_buckets":{"deposit":"b9c67127-9c73-4cac-9f08-60132598a274"},"_deposit":{"created_by":18,"id":"43746","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43746"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043746","sets":["2812:2813:2816"]},"author_link":["71952","71951"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2015-04-01 – 2018-03-31","bibliographic_titles":[{"bibliographic_title":"平成29(2017)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2017 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ウイルス挿入変異によってマウスに発症した腫瘍から、ウイルスタギングを用いて新規がん関連遺伝子群の探索を進め、ヒストンのメチル化修飾を担う酵素群の遺伝子を同定した。こうしたエピジェネティック制御に関わる酵素は、がん細胞の増殖だけでなく、悪性進展の様々な局面（細胞の運動・浸潤，上皮間葉転換（EMT），幹細胞性維持など）において重要な役割を担うことがわかった。さらに、酵素の機能を制御する長鎖非コードRNA（lncRNA）を同定し、lncRNAのがん悪性進展過程における新しい機能を発見した。","subitem_description_type":"Abstract"},{"subitem_description":"Retroviral insertional mutagenesis in mice is one of the powerful strategies for high-throughput identification of novel cancer genes. Using this system, we have frequently identified the genes encoding the enzymes engaged in histone methylation. We discovered that many of the enzymes are involved not only in the tumor initiation but also in the tumor progression such as cell invasion, epithelial mesenchymal transition and maintenance of stem cell properties. Furthermore, we found that long noncoding RNAs played a crucial role in the regulation of these epigenetic enzymes during malignant progression.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K08263, 研究期間(年度):2015-04-01 – 2018-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「挿入変異法で同定されたエピジェネティック制御因子による疾患発症メカニズムの解析」課題番号15K08263\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08263/15K08263seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050088","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30262075"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30262075","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08263/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08263/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08263/15K08263seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K08263/15K08263seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-06"}],"displaytype":"detail","filename":"CA-PR-SUZUKI-T-kaken 2018-6p.pdf","filesize":[{"value":"251.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-SUZUKI-T-kaken 2018-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43746/files/CA-PR-SUZUKI-T-kaken 2018-6p.pdf"},"version_id":"dd3558d2-8e2e-4cd3-8af4-2c37fb3633d5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"挿入変異法で同定されたエピジェネティック制御因子による疾患発症メカニズムの解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"挿入変異法で同定されたエピジェネティック制御因子による疾患発症メカニズムの解析"},{"subitem_title":"Functional analysis of epigenetic regulators in cancer development identified by retroviral insertional mutagenesis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2816"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-06"},"publish_date":"2019-04-06","publish_status":"0","recid":"43746","relation_version_is_last":true,"title":["挿入変異法で同定されたエピジェネティック制御因子による疾患発症メカニズムの解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:03:29.731868+00:00"}