{"created":"2023-07-27T06:50:43.371436+00:00","id":43747,"links":{},"metadata":{"_buckets":{"deposit":"2bb8e7f7-3353-40d5-9350-9577e10004b7"},"_deposit":{"created_by":18,"id":"43747","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43747"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043747","sets":["2812:2813:2819"]},"author_link":["71951","71953"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-25","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2012-04-01 – 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"レトロウイルス挿入変異によってマウスに発症した腫瘍から、ウイルスタギングを用いて新しいがん関連因子群の探索を進め、これまでにヒストンやDNAのメチル化の制御に関与する酵素群を同定した。さらに、これらのエピジェネティクス制御因子が、がんの発症ばかりでなく、がんの転移、薬剤耐性など悪性進展の様々なステップにおいて重要な役割を担っていることを示す新しい知見を得ることができた。","subitem_description_type":"Abstract"},{"subitem_description":"Retroviral insertional mutagenesis in mice is one of the powerful strategies for high-throughput identification of cancer genes. Using this system, we have frequently identified the genes encoding the enzymes engaged in histone or DNA methylation. We have found that some of the enzymes are involved not only in the tumor initiation but also in the malignant tumor progression such as cell invasion and drug resistance.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24590346, 研究期間(年度):2012-04-01 – 2015-03-3","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ウイルス挿入変異法で同定されたエピゲノム制御因子による疾患発症機構の解析」課題番号24590346\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24590346/24590346seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050089","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30262075"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30262075","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24590346/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24590346/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24590346/24590346seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24590346/24590346seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-09"}],"displaytype":"detail","filename":"CA-PR-SUZUKI-T-kaken 2015-5p.pdf","filesize":[{"value":"185.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-SUZUKI-T-kaken 2015-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43747/files/CA-PR-SUZUKI-T-kaken 2015-5p.pdf"},"version_id":"6efdebbd-5ac7-40a6-bf5a-0e72568929f1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ウイルス挿入変異法で同定されたエピゲノム制御因子による疾患発症機構の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ウイルス挿入変異法で同定されたエピゲノム制御因子による疾患発症機構の解析"},{"subitem_title":"Functional characterization of epigenetic regulatory factors identified by retroviral insertional mutagenesis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-09"},"publish_date":"2018-02-09","publish_status":"0","recid":"43747","relation_version_is_last":true,"title":["ウイルス挿入変異法で同定されたエピゲノム制御因子による疾患発症機構の解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:45:00.095096+00:00"}