{"created":"2023-07-27T06:50:43.418904+00:00","id":43748,"links":{},"metadata":{"_buckets":{"deposit":"f12eb0a6-1b8d-4964-a3a7-9cad7052b25f"},"_deposit":{"created_by":18,"id":"43748","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43748"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043748","sets":["2812:2813:2822"]},"author_link":["71952","71951"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-14","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(C) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"レトロウイルス挿入変異によってマウスに発症した腫瘍から、ウイルスタギングを用いて新しいがん関連遺伝子群の探索を進め、これまでにヒストンやDNAのメチル化の制御に関与する酵素群を同定した。さらに、これらのエピジェネティクス制御因子が、がんの発症ばかりでなく、がんの悪性進展の様々なステップにおいて重要な役割を担っていることを示す新しい知見を得ることができた。","subitem_description_type":"Abstract"},{"subitem_description":"Retroviral insertional mutagenesis in mice is one of the important strategies for high-throughput identification of cancer genes. Using this system, we have so far identified most of histone lysine methyltransferase genes and demethylase genes as candidate oncogenes or tumor suppressor genes. We have found that some of the enzymes are involved not only in the tumor initiation but also in the malignant tumor progression such as cell invasion.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:21590303, 研究期間(年度):2009-2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「ゲノムへの挿入変異を利用した疾患関連遺伝子の単離とその機能解析」課題番号21590303\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590303/21590303seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050090","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30262075"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30262075","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590303/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590303/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590303/21590303seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21590303/21590303seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-09"}],"displaytype":"detail","filename":"CA-PR-SUZUKI-T-kaken 2012-5p.pdf","filesize":[{"value":"207.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-SUZUKI-T-kaken 2012-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43748/files/CA-PR-SUZUKI-T-kaken 2012-5p.pdf"},"version_id":"02a65751-9601-4226-9650-a0125dc36920"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ゲノムへの挿入変異を利用した疾患関連遺伝子の単離とその機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ゲノムへの挿入変異を利用した疾患関連遺伝子の単離とその機能解析"},{"subitem_title":"Functional characterization of candidate disease genes identified by the efficient insertional mutagenesis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-09"},"publish_date":"2018-02-09","publish_status":"0","recid":"43748","relation_version_is_last":true,"title":["ゲノムへの挿入変異を利用した疾患関連遺伝子の単離とその機能解析"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:28:38.787816+00:00"}