{"created":"2023-07-27T06:50:43.507492+00:00","id":43750,"links":{},"metadata":{"_buckets":{"deposit":"e00da620-4b90-4127-97b4-2c6b44efcfba"},"_deposit":{"created_by":18,"id":"43750","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43750"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043750","sets":["2812:2813:2819"]},"author_link":["69424","71956"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-02","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2012-04-01 – 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"転移巣における分子標的薬耐性機構を解明するために、EGFR変異肺がんおよびALK融合遺伝子陽性肺がん細胞株を用い、がん性胸水、骨病変（骨転移）、脳病変（脳転移）における分子標的薬耐性のin vivoイメージングモデルを確立した。これらのモデルを用い、一つの腫瘍においても複数の因子により耐性が惹起されること、耐性克服には併用療法の副作用に留意した戦略を立てる必要があることを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"To elucidate mechanism of targeted drug resistance in metastatic lesions, we established in vivo imaging models for pleural carcinomatosis and bone/brain metastases, which are resistant to targeted drugs, of EGFR mutant or ALK fusion positive lung cancer cell lines. We found that resistant tumors consist of a heterogeneous mixture of functionally distinct cancer cells with different resistant mechanisms. Moreover, our observation indicated that we should be careful for toxicity of combined therapy which overcome targeted drug resistance caused by multiple mechanisms.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:24390209, 研究期間(年度):2012-04-01 – 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「肺がんの転移と分子標的薬耐性を克服する統合的研究」課題番号24390209\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24390209/24390209seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050092","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30294672"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30294672","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24390209/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24390209/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24390209/24390209seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24390209/24390209seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-09"}],"displaytype":"detail","filename":"CA-PR-YANO-S-kaken 2015B-6p.pdf","filesize":[{"value":"143.6 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-YANO-S-kaken 2015B-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43750/files/CA-PR-YANO-S-kaken 2015B-6p.pdf"},"version_id":"44fc74c3-c2d0-44d9-9fab-6e9fa4efa347"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肺がんの転移と分子標的薬耐性を克服する統合的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肺がんの転移と分子標的薬耐性を克服する統合的研究"},{"subitem_title":"Study to overcome metastasis and targeted drug-resistance of lung cancer","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-09"},"publish_date":"2018-02-09","publish_status":"0","recid":"43750","relation_version_is_last":true,"title":["肺がんの転移と分子標的薬耐性を克服する統合的研究"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:44:58.689096+00:00"}