{"created":"2023-07-27T06:50:43.551411+00:00","id":43751,"links":{},"metadata":{"_buckets":{"deposit":"abddf1e7-cd85-49ba-8f93-66d6bb295642"},"_deposit":{"created_by":18,"id":"43751","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43751"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043751","sets":["2812:2813:2819"]},"author_link":["71957","69424"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-02","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"6p.","bibliographicVolumeNumber":"2010-04-01 – 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 新学術領域研究(研究領域提案型) 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"腫瘍微小環境の線維芽細胞が産生するHGFなどの増殖因子が、EGFR変異肺がんやALK融合遺伝子陽性肺がん細胞において、分子標的薬耐性を惹起することを明らかにした。さらに、これらの増殖因子受容体の活性化を阻害すれば、微小環境による分子標的薬耐性が解除できることを示した。\n一方、胸膜中皮腫の同所移植モデルにおいて、胸膜中皮腫細胞と線維芽細胞は、悪性サイトカインネットワークを形成することで腫瘍進展を促進しており、このサイトカインネットワークの構成因子が治療標的となることを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"We found that microenvironment-derived growth factors, including HGF, induced resistance to tyrosine kinase inhibitors in EGFR mutant or ALK-fusion gene positive lung cancer. The resistance caused by microenvironment could be overcome by concomitant inhibition of growth factor receptors. In the orthotopic model of mesothelioma, we discovered that mesothelioma cells and fibroblasts formed the vicious cytokine network and promoted tumor progression, indicating that factors involved in this network would be ideal therapeutic targets for mesothelioma.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:22112010, 研究期間(年度):2010-04-01 – 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「呼吸器悪性腫瘍の微小環境の特性を標的とした新規制御法の開発」課題番号22112010\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PLANNED-22112010/22112010seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050093","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=30294672"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=30294672","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22112010/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22112010/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PLANNED-22112010/22112010seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PLANNED-22112010/22112010seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-09"}],"displaytype":"detail","filename":"CA-PR-YANO-S-kaken 2015-6p.pdf","filesize":[{"value":"147.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-YANO-S-kaken 2015-6p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43751/files/CA-PR-YANO-S-kaken 2015-6p.pdf"},"version_id":"150cd65b-f6d6-44b1-8055-84c2b3163966"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"呼吸器悪性腫瘍の微小環境の特性を標的とした新規制御法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"呼吸器悪性腫瘍の微小環境の特性を標的とした新規制御法の開発"},{"subitem_title":"Development of novel therapy targeting microenvironment in respiratory malignancy","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-09"},"publish_date":"2018-02-09","publish_status":"0","recid":"43751","relation_version_is_last":true,"title":["呼吸器悪性腫瘍の微小環境の特性を標的とした新規制御法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:44:57.199453+00:00"}