{"created":"2023-07-27T06:50:43.688724+00:00","id":43755,"links":{},"metadata":{"_buckets":{"deposit":"670c31c2-4114-409a-8b47-3e900536d287"},"_deposit":{"created_by":18,"id":"43755","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43755"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043755","sets":["2812:2813:2819"]},"author_link":["71960","71962"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-26","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2013-04-01 – 2015-03-31","bibliographic_titles":[{"bibliographic_title":"平成26(2014)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2014 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"造血幹細胞集団を構成する個々のクローンは、その能力や動態が大きく異なる。本研究では、幹細胞クローンの優劣を決定する機構を理解するため、細胞競合という概念から取り組んだ。特に、細胞競合現象に関与するシグナルとしてRasに着目して研究を進めた。その結果、Ras/Raf/Erkシグナル制御に関与する分子として知られるSpred1が、生体内での造血幹細胞優位性の決定に寄与することを明らかにした。Spred1の挙動が造血幹細胞の能力の変化を介して、老化や白血病化に寄与する可能性も示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"It has been shown that quality of individual hematopoietic stem cells are highly variable. In this study, we analyzed functions of molecules in Ras signals in hematopoetic stem cell competition during hematopoietic reconstitution. We found that Spred1, a negative regulator of Ras/Raf/Erk, plays a critical role in dominancy of hematopoietic stem cells in a competitive assay in vivo. Further studies of Spred1-mediated control of self-renewal activity of hematopoietic stem cells would lead to deep understanding of stem cell aging and tumorigenesis.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:25670447, 研究期間(年度):2013-04-01 – 2015-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「細胞競合を介した幹細胞クローン増幅機構の解明」課題番号25670447\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25670447/25670447seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050097","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90343350"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90343350","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25670447/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25670447/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25670447/25670447seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25670447/25670447seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-09"}],"displaytype":"detail","filename":"CA-PR-HIRAO-A-kaken 2015-4p.pdf","filesize":[{"value":"164.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-HIRAO-A-kaken 2015-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43755/files/CA-PR-HIRAO-A-kaken 2015-4p.pdf"},"version_id":"70d1dbce-b9b0-4af6-8dee-036ce9667bd5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"細胞競合を介した幹細胞クローン増幅機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細胞競合を介した幹細胞クローン増幅機構の解明"},{"subitem_title":"Mechanisms of expansion of hematopoietic stem cell clones","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2819"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-09"},"publish_date":"2018-02-09","publish_status":"0","recid":"43755","relation_version_is_last":true,"title":["細胞競合を介した幹細胞クローン増幅機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T10:44:50.131727+00:00"}