{"created":"2023-07-27T06:50:43.778211+00:00","id":43758,"links":{},"metadata":{"_buckets":{"deposit":"c466f32b-ee41-44c8-b59b-1d3e9502c16c"},"_deposit":{"created_by":18,"id":"43758","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43758"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043758","sets":["2812:2813:2822"]},"author_link":["71960","71961"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 挑戦的萌芽研究 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"蛋白翻訳・細胞成長を司るmTOR複合体1は、様々な腫瘍組織において、その発がんや悪性進展過程におけるがん動態と深くかかわっている。我々は、mTOR複合体1活性制御が白血病幹細胞分化にとって極めて重要な因子ではないかと考え、マルチオミクス解析システム解析を行った。その結果、mTOR複合体1欠損により、多くの分子においてリン酸化状態の変動が確認された。この手法により、白血病幹細胞制御因子に関する多くの手掛かりが得られると考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"mTOR is an evolutionarily conserved kinase in eukaryotes that plays a critical role in sensing and responding to factors such as nutrient availability, energy sufficiency, stress, hormones, and mitogens. Since it was reported that mTOR complex 1(mTORC1) dysregulation promotes leukemogenesis and depletes hematopoietic stem cells, we attempted to understand the pathological roles of mTORC1 in leukemia behavior by multi-omics technology. In this study, we found that there are particular cell population showing obvious resistance to mTORC1 inactivation, and found several candidate molecules that are involved in the regulation of leukemia stem cells.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:23650593, 研究期間(年度):2011","subitem_description_type":"Other"},{"subitem_description":"出典：研究課題「マルチオミクス解析システムによる白血病幹細胞分化制御機構の解明」課題番号23650593\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23650593/23650593seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050100","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90343350"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90343350","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650593/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650593/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23650593/23650593seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23650593/23650593seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-09"}],"displaytype":"detail","filename":"CA-PR-HIRAO-A-kaken 2012-4p.pdf","filesize":[{"value":"220.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-HIRAO-A-kaken 2012-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43758/files/CA-PR-HIRAO-A-kaken 2012-4p.pdf"},"version_id":"a40f50a2-3131-4f6c-8ff1-722b33ba4c57"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"マルチオミクス解析システムによる白血病幹細胞分化制御機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マルチオミクス解析システムによる白血病幹細胞分化制御機構の解明"},{"subitem_title":"Understanding of molecular mechanisms regulating leukemia stem cell behavior by multi-omics analysis","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-09"},"publish_date":"2018-02-09","publish_status":"0","recid":"43758","relation_version_is_last":true,"title":["マルチオミクス解析システムによる白血病幹細胞分化制御機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:28:35.756323+00:00"}