{"created":"2023-07-27T06:50:43.822705+00:00","id":43759,"links":{},"metadata":{"_buckets":{"deposit":"4a65ab1b-1226-4499-9e4d-c101570ad3e3"},"_deposit":{"created_by":18,"id":"43759","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43759"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043759","sets":["2812:2813:2822"]},"author_link":["71960","71961"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"5p.","bibliographicVolumeNumber":"2009-2011","bibliographic_titles":[{"bibliographic_title":"平成23(2011)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2011 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、細胞老化・寿命制御シグナルの知見をもとに、正常幹細胞と白血病幹細胞の共通性と相違点を明らかにし、白血病幹細胞の実体を解明することを目指した。その結果、寿命制御遺伝子として知られているFOXOが、白血病幹細胞の維持に必須の役割を果たしていることが明らかとなった。また、細胞老化シグナルとして知られるRasの活性化は、細胞分化特異的な因子と関連し、白血病化の決定的因子として機能していると考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we investigated roles of senescence/longevity related molecules in the development, maintenance and differentiation of leukemia stem cells. We found that FOXO, which is a critical regulator of longevity of C. elegans, is essential for maintenance of leukemia stem cells. In addition, it was suggested that constitutive Ras, which is known to induce cellular senescence, causes leukemogenesis, collaborating with factors controlling cellular differentiation.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"出典：研究課題「細胞老化・寿命制御シグナルによる白血病幹細胞の発生・維持・分化」課題番号21390290\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390290/21390290seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050101","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90343350"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90343350","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390290/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390290/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390290/21390290seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-21390290/21390290seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-09"}],"displaytype":"detail","filename":"CA-PR-HIRAO-A-kaken 2012B-5p.pdf","filesize":[{"value":"281.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-HIRAO-A-kaken 2012B-5p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43759/files/CA-PR-HIRAO-A-kaken 2012B-5p.pdf"},"version_id":"1dc5e182-f439-47ee-84e9-145fa7025934"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"細胞老化・寿命制御シグナルによる白血病幹細胞の発生・維持・分化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細胞老化・寿命制御シグナルによる白血病幹細胞の発生・維持・分化"},{"subitem_title":"Roles of longevity/senescence-relating molecules in the development, maintenance and differentiation of leukemia stem cells","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2822"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-09"},"publish_date":"2018-02-09","publish_status":"0","recid":"43759","relation_version_is_last":true,"title":["細胞老化・寿命制御シグナルによる白血病幹細胞の発生・維持・分化"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T13:28:30.294916+00:00"}