{"created":"2023-07-27T06:50:43.867948+00:00","id":43760,"links":{},"metadata":{"_buckets":{"deposit":"995d8607-3e73-4050-86de-38f93b8a24ad"},"_deposit":{"created_by":18,"id":"43760","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43760"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043760","sets":["2812:2813:2825"]},"author_link":["71960","71961"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-05-21","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2006-2008","bibliographic_titles":[{"bibliographic_title":"平成20(2008)年度 科学研究費補助金 基盤研究(B) 研究成果報告書"},{"bibliographic_title":"2008 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{}],"nameIdentifiers":[{},{}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"正常造血幹細胞と白血病幹細胞の共通性を解明するアプローチとして、核小体に焦点を当てて研究を進めた。核小体分子Nucleosteminは、未分化な造血幹細胞に高い発現が認められた。Nucleosteminの発現をGFPによってモニターするレポーターシステムを構築し、造血系で解析したところ、正常造血および骨髄性白血病において、未分化細胞を濃縮することができた。これらの知見は、将来の白血病治療薬の標的となる分子の特定に寄与することが期待された。","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:18390281, 研究期間(年度):2006-2008","subitem_description_type":"Other"},{"subitem_description":"出典：「核小体分子の発現・機能解析による正常および白血病幹細胞の未分化性維持機構の解明」研究成果報告書　課題番号18390281\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所））\n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18390281/18390281seika/)を加工して作成","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050102","subitem_identifier_reg_type":"JaLC"}]},"item_9_publisher_17":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"金沢大学がん進展制御研究所"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=90343350"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=90343350","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390281/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390281/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18390281/18390281seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-18390281/18390281seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-09"}],"displaytype":"detail","filename":"CA-PR-HIRAO-A-kaken 2009-4p.pdf","filesize":[{"value":"197.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-HIRAO-A-kaken 2009-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43760/files/CA-PR-HIRAO-A-kaken 2009-4p.pdf"},"version_id":"39c7ffe0-e917-4bc0-9df0-251cc500a417"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"核小体分子の発現・機能解析による正常および白血病幹細胞の未分化性維持機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"核小体分子の発現・機能解析による正常および白血病幹細胞の未分化性維持機構の解明"},{"subitem_title":"Molecular mechanisms for regulation of hematopoietic and leukemia stem cell population by nucleolar molecules","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2825"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-09"},"publish_date":"2018-02-09","publish_status":"0","recid":"43760","relation_version_is_last":true,"title":["核小体分子の発現・機能解析による正常および白血病幹細胞の未分化性維持機構の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2023-07-27T14:15:19.596422+00:00"}