{"created":"2023-07-27T06:50:43.957029+00:00","id":43762,"links":{},"metadata":{"_buckets":{"deposit":"dc5c3ecb-ae95-482e-976b-21d63ee8fa20"},"_deposit":{"created_by":18,"id":"43762","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"43762"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00043762","sets":["2812:2813:2817"]},"author_link":["48006","71971"],"item_9_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4p.","bibliographicVolumeNumber":"2015-04-01 – 2017-03-31","bibliographic_titles":[{"bibliographic_title":"平成28(2016)年度 科学研究費補助金 若手研究(B) 研究成果報告書"},{"bibliographic_title":"2016 Fiscal Year Final Research Report","bibliographic_titleLang":"en"}]}]},"item_9_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Echizen, Kanae"}],"nameIdentifiers":[{"nameIdentifier":"71971","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20743834","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20743834"}]}]},"item_9_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"H.pyroli感染に起因する慢性炎症は胃がん発生の主な原因の一つである。本研究では、胃炎組織に浸潤してきた間質細胞から分泌されるTNF-αによってNox1複合体が活性化するメカニズムを明らかにし、これらが胃粘膜の過形成や化生の形成に関わる可能性を明らかにした。本研究で行った実験の結果は、胃炎組織で異常腺管が発生するメカニズムを解明する一端となる、新たな知見となった。またNox1複合体を阻害することによって、胃がん発生を予防する可能性について示すことが出来た。","subitem_description_type":"Abstract"},{"subitem_description":"H.pyroli infection-associated gastritis is one of the main causes of stomach cancer. However, molecular mechanism of gastritis formation is still unrevealed.In previous studies, our group reported that bone marrow-derived cells (BMDCs)-derived TNF-α promotes gastric tumor development. In this study, we investigated the molecular and genetic functions of Noxo1, which is a target of TNF-α, in gastritis and its associated tumorigenesis by using gastric cancer cells, gastritis model mice (C2mE mice) and sporadic gastric tumor model mice (Gan mice). Administration of a Nox inhibitor suppressed proliferation of gastric cancer cells in vitro and further inhibited metaplasia/hyperplasia formation in C2mE mice. We also found that this inhibitor also suppressed proliferation of stem-like cells in the neck region of stomach glands. Accordingly, Noxo1 and the Nox1 complex are possible effective preventive or therapeutic targets for gastritis and gastric cancer.","subitem_description_type":"Abstract"}]},"item_9_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究課題/領域番号:15K18405, 研究期間(年度):2015-04-01 – 2017-03-31","subitem_description_type":"Other"},{"subitem_description":"出典：「炎症性微小環境で活性化されるNox複合体/ROSによる胃がん発生機序の解明」研究成果報告書　課題番号15K18405\n（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） \n（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K18405/15K18405seika/）を加工して作成","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん進展制御研究所","subitem_description_type":"Other"}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00050104","subitem_identifier_reg_type":"JaLC"}]},"item_9_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/search/?qm=20743834"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/search/?qm=20743834","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K18405/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K18405/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K18405/15K18405seika/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K18405/15K18405seika/","subitem_relation_type_select":"URI"}}]},"item_9_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"越前, 佳奈恵"}],"nameIdentifiers":[{"nameIdentifier":"48006","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20743834","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20743834"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-11"}],"displaytype":"detail","filename":"CA-PR-ECHIZAN-K-kaken 2017-4p.pdf","filesize":[{"value":"260.5 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CA-PR-ECHIZAN-K-kaken 2017-4p.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/43762/files/CA-PR-ECHIZAN-K-kaken 2017-4p.pdf"},"version_id":"5242958c-abdf-4b3d-98fe-38af2bfecbee"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"炎症性微小環境で活性化されるNox複合体/ROSによる胃がん発生機序の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"炎症性微小環境で活性化されるNox複合体/ROSによる胃がん発生機序の解明"},{"subitem_title":"Functional analysis of Noxo1/Nox1 complex in gastritis and inflammation-associated gastric tumor development","subitem_title_language":"en"}]},"item_type_id":"9","owner":"18","path":["2817"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-11"},"publish_date":"2018-06-11","publish_status":"0","recid":"43762","relation_version_is_last":true,"title":["炎症性微小環境で活性化されるNox複合体/ROSによる胃がん発生機序の解明"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-07-01T05:37:56.070712+00:00"}